现代中医临床Issue(1)：44-48,5.DOI:10.3969/j.issn.2095-6606.2015.01.013
清热解毒箍围法促进糖尿病大鼠感染性溃疡愈合的实验研究∗
Heat-clearing and detoxicating surrounding method improves infective ulcer in diabetes rats
摘要
Abstract
Objective To explore the influence of heat-clearing and detoxicating surrounding method on infective ulcer in diabetes rats. Methods 60 rats were randomly divided into model group, conventional therapy group, external application of penicillin group and heat-clearing and detoxicating surrounding group , with 15 rats in each group. Each group was treated at the first day after modeling. 0. 3 ml muscle injection of normal saline was given to the model group, 0. 3 ml muscle injection of penicillin solution was given to the conventional therapy group, conventional treatment combining external application of 0. 9 ml penicillin solution were given to external application of penicillin group, and conventional treatment com-bining surrounding drugs on the wound were given to the heat-clearing and detoxicating surrounding group. The wound surface changes, temperature of skin around the wound, the ulcer space; hyaluronic acid were observed after modeling. Results Compared to the heat-clearing and detoxicating group, skin temperature around the wound the model group, conventional therapy group and external application of penicillin group decreased significantly at the 3, 7 and 14 d. Compared to the model group, the ulcer space of heat-clearing and detoxicating surrounding group and external application of penicillin group decreased significantly at 3 , 7 and 14 d after modeling ( P <0. 01 ) . Compared to the conventional therapy group, the ulcer space of heat-clearing and detoxicating surrounding group and external application of penicillin group decreased significantly at the 3 , 7 and 14 d after modeling ( P<0. 01 ) . Compared to the external application of penicillin group, the ulcer space of heat-clearing and detoxicating surrounding group decreased significantly at the 3 and 7 d after modeling ( P <0. 01 ) , the spherical detection showed P<0. 05. Among the four groups, hyaluronic acid of heat-clearing and detoxicating sur-rounding group and external application of penicillin group were significantly higher than the model group at the 3 , 7 , 14 and 21 d after modeling ( P<0. 01 ) , the same things happened when compared to the conventional therapy group ( P<0. 01 ) , and the hyaluronic acid of heat-clearing and detoxicating sur-rounding group was significantly higher than the external application of penicillin group (P<0. 01). The comparision of hyaluronic acid at different time in each group as shown below:hyaluronic acid of 7 d and 14 d was higher than 3 d (P<0. 01), hyaluronic acid of 21 d was lower than 7 d and 14 d(P<0. 01). Conclusion Heat-clearing and detoxicating surrounding method improves infective ulcer of diabetes rats.关键词
糖尿病/感染性溃疡/清热解毒/箍围法/大鼠Key words
diabetic ulcer/heat-clearing and detoxicating/drug surrounding method/rats分类
医药卫生引用本文复制引用
赵谏,王连洁,孟艳娇,于秀辰..清热解毒箍围法促进糖尿病大鼠感染性溃疡愈合的实验研究∗[J].现代中医临床,2015,(1):44-48,5.基金项目
北京中医药大学自主选题中青年教师资助项目(No．2011-JYBZZ-JS066) （No．2011-JYBZZ-JS066）
