波谱学杂志Issue(4)：477-487,11.
一种用于fMRI的嗅觉刺激装置设计与验证
Design and Evaluation of an Olfactometer for fMRI Studies
摘要
Abstract
We developed a computer-controlled olfactometer for delivering odors for functional magnetic resonance imaging (fMRI) experiments. The olfactometer is consisted of an air transport system and a control system. Odors are produced and delivered by the air transport system, in which air flow first passes through liquid mixed with odorants in gas-washing bottles and then is delivered to the test subjects. The control system provides a user interface for operating the device and controlling solenoid valves. The system is based on virtual instrumentation technology, and the software for it is written in LabVIEW. The device was tested on a Siemens 3.0 T MRI scanner. Block-design fMRI data were collected from one healthy subject who was stimulated with two odors, isoamyl acetate and pyridine. The raw fMRI data were processed with Matlab-based SPM8 and MarsBaR toolbox. Region-of-interest (ROI)-based analysis was performed for the left orbitofrontal cortex and left insula. It was found that the signal changes in the two ROIs were basically in compliance with the stimulation paradigm, but the signal changes induced by pyridine were more robust than that produced by isoamyl acetate stimulation. In the same ROI, the signal intensity changes caused by pyridine were higher than that induced by isoamyl acetate.关键词
功能磁共振成像(fMRI)/刺激装置/嗅觉/刺激Key words
fMRI/olfactometer/olfactory/stimulation分类
数理科学引用本文复制引用
王骁冠,王慧,常严,徐雅洁,张广才,蒋瑞瑞,杨晓冬..一种用于fMRI的嗅觉刺激装置设计与验证[J].波谱学杂志,2014,(4):477-487,11.基金项目
中科院科研装备研制资助项目(YZ201253)，苏州市科技资助项目(SYG201125) （YZ201253）
