波谱学杂志Issue(1)：95-104,10.DOI:10.11938/cjmr20150111
一维NOE NMR技术用于蒂巴因衍生物的立体结构研究
Stereochemistry and Spectral Assignment of Thebaine Derivatives:A 1D NOESY NMR Study
姜丹 1徐佳2
作者信息
- 1. 军事医学科学院 毒物药物研究所，北京 100850
- 2. 北京协和医院，北京100730
- 折叠
摘要
Abstract
Using analgesic dihydroetophine (compound 1) as the example, the stereochemical structures of thebaine derivatives were studied by NMR spectroscopy. Multiple-frequency selective excitation double pulsed field gradient spin echo 1D NOESY experiments in combination with 2D NMR techniques were used to assign the severely overlapped 1H and 13C resonances from compound 1. According to results of 1D NOESY experiments and the coupling constants measured, the conformational property and C-7 configuration of compound 1 in deuteriochloroform solution were elucidated.关键词
核磁共振(NMR)/一维NOESY(1D NOESY)/蒂巴因衍生物/立体化学Key words
NMR/1D NOESY/thebaine/derivatives/stereochemistry分类
数理科学引用本文复制引用
姜丹,徐佳..一维NOE NMR技术用于蒂巴因衍生物的立体结构研究[J].波谱学杂志,2015,(1):95-104,10.
