波谱学杂志Issue(1)：123-140,18.DOI:10.11938/cjmr20150114
生物固体核磁共振中样品发热的研究进展
Heating of Biological Samples in Studies of MAS Solid-State NMR
摘要
Abstract
Magic-angle-spinning (MAS) solid-state NMR studies of biomolecules involve application of rapid sample rotation and radiofrequency pulsing, both of which can increase the sample temperature significantly, causing distorted spectra, sample dehydration and even sample degradation. In this review, the mechanisms leading to bio-sample heating in MAS solid-state NMR experiments are first introduced. The importance of sample temperature monitoring is then emphasized. Finally, we present the methods that can be used to to alleviate the problem, including optimization of sample preparation, selecting optimal NMR parameters, and improving NMR spectrometer hardware such as the probes.关键词
固体核磁共振(solid-state NMR)/样品发热/魔角旋转/射频场Key words
solid-state NMR/sample heating/magic angle spinning/radiofrequency分类
数理科学引用本文复制引用
唐新启,张正逢,杨俊..生物固体核磁共振中样品发热的研究进展[J].波谱学杂志,2015,(1):123-140,18.基金项目
国家自然科学基金资助项目(21075133,21173259) （21075133,21173259）
