吉林大学学报（医学版）Issue(4)：842-846,5.DOI:10.13481/j.1671-587x.20140430
转移抑制因子1和钙激活蛋白43在食管鳞状细胞癌组织中的表达及其临床意义
Expressions of MTSS1 and Cap43 in esophageal squamous cell carcinoma tissue and their clinical significances
摘要
Abstract
Objective To investigate the expressions of metastasis suppressor 1 (MTSS1 )and calcium activated protein 43 (Cap43)in esophageal squamous cell carcinoma (ESCC)tissue,and to clarify the relationship between the expressions of MTSS1,Cap43 and the clinicopathological features of ESCC.Methods 80 cases of ESCC tissue and 30 cases of normal adjacent-cancer tissue were collected,and the protein and mRNA expressions of MTSS1 and Cap43 in ESCC tissue and normal tissue were detected by streptavidin-perosidase (SP)immunohistochemistry and RT-PCR;their relationships with the clinicopathological features of ESCC were analyzed.Results The positive expression rate of MTSS1 in normal esophagus tissue was significantly higher than that in ESCC tissue detected by SP (83.3%vs 21.3%,P<0.01)and RT-PCR (0.703±0.085 vs 0.295±0.065,P<0.01),However,the positive expression rate of Cap43 in normal esophagus tissue was significantly lower than that in ESCC tissue by SP method (16.7%vs 76.3%,P<0.01)and by RT-PCR (0.236±0.052 vs 0.693±0.078,P<0.01).The mRNA expression levels of MTSS1 and Cap43 in ESCC tissue were significantly related with the invasive extent, histological differentiation,TNM stage,and lymphatic metastases (P<0.05)of ESCC,but not related with the age,sex,tumor size and pathological type (P>0.05). The mRNA expression of MTSS1 was negatively correlated with the expression of Cap43 (r=-0.457,P<0.05).Conclusion The low-expression of MTSS1 and over-expression of Cap43 in ESCC tissue may contribute to tumor invasion and metastasis;the imbalance of MTSS1 and Cap43 may be one of the mechanisms of tumor invasion and metastases.关键词
食管肿瘤/鳞状细胞癌/转移抑制因子 1/钙激活蛋白43Key words
esophageal neoplasms/squamous cell carcinoma/metastasis suppressor 1/calcium activated protein 43分类
医药卫生引用本文复制引用
寇炜,窦春江,周云松,兰咏梅,顾巧玲..转移抑制因子1和钙激活蛋白43在食管鳞状细胞癌组织中的表达及其临床意义[J].吉林大学学报（医学版）,2014,(4):842-846,5.基金项目
甘肃省教育厅科研基金资助课题（1118B-02）；西北民族大学中央高校基本科研业务费专项基金资助课题 （）
