吉林大学学报（医学版）Issue(4)：880-883,4.DOI:10.13481/j.1671-587x.20140438
不同剂量普奈洛尔治疗婴儿血管瘤的疗效评价
Evaluation on efficacy of different doses of propranolol in treatment of infantile hemangioma
摘要
Abstract
Objective To investigate the clinical effects of different doses of propranolol in treatment of infantile mixed and deep hemangioma,and to provid theoretical and experimental evidence for the treatment of hemangioma. Methods The selected 62 patients with mixed and deep hemangioma were divided randomly into low dose (1.5mg·kg-1 ·d-1 )and high dose (3.0 mg·kg-1 ·d-1 )of propranolol groups,3 times a day,6 months as a course,the changes in hemangioma size and the incidence of adverse reactions were recorded.Results The efficacy was evaluated using Achauer system.The total effective rate was 80.65% in low dose of propranolol group and 93.55% in high dose of propranolol group,including 6 cases of class Ⅰ (poor),9 cases of class Ⅱ (moderate), 11 cases of classⅢ (good),and 5 cases of class Ⅳ (excellent)in low dose propranolol group;while 2 cases of class Ⅰ (poor),4 cases of class Ⅱ (moderate),10 cases of class Ⅲ (good)and 15 cases of Ⅳ (excellent)in high dose of propranolol group.The efficacy in high dose of proprandol group was significantly better than that in low dose of proprandol group (P<0.05),there were no significant differences in the efficacies between different sites and different types (P>0.05)and there was no significant difference in the incidence of adverse reaction between two groups (P>0.05).Conclusion The efficacy of oral 3.0 mg·kg-1 ·d-1 propranolol in treatment of infantile mixed and deep hemangioma is increased significantly, and there is no significant adverse reactions after increasing doses.Therefore,high dose of propranolol should be recommended in order to improve the therapeutic effect.关键词
血管瘤/普奈洛尔/疗效/不良反应Key words
hemangioma/propranolol/therapeutic effect/adverse reaction分类
医药卫生引用本文复制引用
钟淑霞,陶育纯,周俊峰,姚蕾,李珊山..不同剂量普奈洛尔治疗婴儿血管瘤的疗效评价[J].吉林大学学报（医学版）,2014,(4):880-883,4.基金项目
吉林省科技厅科技发展计划项目资助课题 （）
