吉林大学学报（医学版）Issue(5)：925-928,4.DOI:10.13481/j.1671-587x.20140503
姜黄素对脑缺血再灌注损伤大鼠脑组织中NO和S100β水平的影响
Influence of curcumin in NO and S1 00βlevels in brain tissue of rats after focal cerebral ischemia reperfusion inj ury
摘要
Abstract
to observe the infarction volume.Nitrate reductase assay was used to detect the level of NO in brain tissue of the rats.The level of S100βin brain was detected by ELISA method.Results Compared with model group,the brain infarction volumes of the rats 24 and 72 h after cerebral ischemia reperfusion in curcumin group were significantly decreased (P<0.05).Compared with sham operation group,the NO and S100βlevels in the brain tissue 24 and 72 h after cerebral ischemia reperfusion of the rats in model group were significantly increased(P<0.05);compared with model group,the levels of NO in the brain tissue 24 and 72 h after cerebral ischemia reperfusion in curcumin group were remarkably decreased (P<0.05);compared with modee group,the level of S100βin the brain tissue 72 h after cerebral iscemia reperfusion in curcumin group was remarkably decreased (P < 0.05 ). Conclusion Curcumin can significantly reduce the degree of ischemia reperfusion injury in the rats and reduce the levels of NO and S100βin brain tissue,which suggests that the decrease of NO and S100βlevels in brain tissue may be associated with the neuroprotective effect of curcumin.关键词
姜黄素/脑缺血再灌注/一氧化氮/S100βKey words
curcumin/cerebral ischemia reperfusion/nitric oxide/S100β分类
医药卫生引用本文复制引用
赵朝华,吴树强,苟兴春,米亚静,杨吉平,史利利,成娟娟..姜黄素对脑缺血再灌注损伤大鼠脑组织中NO和S100β水平的影响[J].吉林大学学报（医学版）,2014,(5):925-928,4.基金项目
国家自然科学基金资助课题（81071060）；陕西省科技厅科技计划项目资助课题（2013JQ3017）；西安医学院科研基金资助课题 （）
