吉林大学学报（医学版）Issue(5)：1051-1057,7.DOI:10.13481/j.1671-587x.20140528
人血浆抗谷胶蛋白 IgA和IgG 抗体与精神分裂症发病及临床表型的关联性分析
Analysis on association between anti-gliadin IgA and anti-gliadin IgG antibodies and schizophrenia in Chinese Han population
摘要
Abstract
Objective To detect the levels of anti-gliadin IgA and anti-gliadin IgG antibodies in the plasma of the patients with schizophrenia, and to investigate the association between schizophrenia and anti-gliadin IgA, IgG bodies in a Chinese Han population, and to clarify the effect of gliadin on the occurrence of schizophrenia.Methods The plasma samples were collected from 428 patients with schizophrenia and 555 cases of normal control subjects in a Chinese Han population.The gliadin antibodies in plasma,including IgA and IgG,were tested using a native anti-gliadin ELISA test kit.The positive rates of plasma anti-gliadin IgA,and anti-gliadin IgG were tested by Chi-square test between the patients with schizophrenia and control subj ects. The differences of the levels of anti-gliadin IgA and anti-gliadin IgG were tested by Mann-Whitney U test between the patients with schizophrenia and control subjects.Results Compared with normal control group,the anti-gliadin IgA level and the positive rate of plasma anti-gliadin IgA in patient group were increased significantly(P<0.01),but there were no significant differences of the positive rate and the level of anti-gliadin IgG in plasma between patient and control groups (P>0.05).The anti-gliadin IgA levels in the patients with delusion of observation,delusion of being revealed,delusion of persecution, delusion of j ealousy, delusion of grandeur, incoherence of thinking, illogic thought, bizarre behavior,aggressive behavior,hallucination-delusion syndrome,poverty of thought,emotional blunting/apathy and aboulia were higher than that of the normal controls (P<0.05);the anti-gliadin IgG levels in the patients with delusion of being revealed and delusion of grandeur were higher than that of the normal controls (P<0.05 ). Conclusion Gliadin is associated with the onset of schizophrenia in Chinese Han population, and the plasma antibodies of gliadin maybe play an important rale in the onset of schizophrenia.关键词
精神分裂症/表型/谷蛋白/抗谷胶蛋白 IgA抗体/抗谷胶蛋白 IgG抗体/酶联免疫分析Key words
schizophrenia/phenotype/anti-gliadin IgA/anti-gliadin IgG/enzyme-labeled immunosorbent assay分类
生物科学引用本文复制引用
王嘉欣,武宁,杜伟利,赵鑫丽,赵晓霞,惠李,王珍琦,张萱..人血浆抗谷胶蛋白 IgA和IgG 抗体与精神分裂症发病及临床表型的关联性分析[J].吉林大学学报（医学版）,2014,(5):1051-1057,7.基金项目
国家自然科学基金资助课题（30700257）；教育部新世纪优秀人才支持计划项目资助课题（NCET-10-0449）；教育部博士点基金项目资助课题（20120061110072）；吉林大学白求恩计划 B 项目资助课题 （）
