吉林大学学报（医学版）Issue(6)：1192-1196,5.DOI:10.13481/j.1671-587x.20140614
生长抑素对糖尿病大鼠早期视网膜电图的影响
Effect of somatostatin on early electroretinogram in diabetic rats
摘要
Abstract
Objective To investigate the effect of somatostatin on the electrophysiological changes of early diabetic rats,and to clarify its therapeutic effects on retinopathy in early diabetic rats.Methods 20 Wistar male rats, which were induced into diabetic rat models by intraperitoneal injection of streptozotocin (STZ),were randomly divided into somatostatin therapy group and model control group, 10 in each group.The rats in somatostatin therapy group were injected with somatostatin 10μg·kg-1 ·d-1,for 8 weeks;the rats in model control group received the same volume of saline.Another 10 male Wistar rats were used as normal control group.The changes of blood glucose and electroretinogram were measured, and the indicators were used for statistical analysis. Results Compared with model control group,the blood glucose was declined in somatostatin therapy group at the 8th week (P<0.05).Compared with normal control group,the latent periods of a-wave,b-wave of rod-response and max-response were significantly extended in somatostatin therapy group and model control group at the 1 st, 2nd,4th,6th,and 8th week (P<0.05).The latent periods of a-wave,b-wave of rod-response and max-response in somatostatin therapy group were shorter than those in model control group at the 8th week (P<0.05 ). Compared with model control group, the amplitude had no changes at each observation time point in somatostatin therapy group (P>0.05).Conclusion Somatostatin has a therapeutic effect on early diabetic retinopathy in rats.关键词
生长抑素/糖尿病视网膜病变/视网膜电图/大鼠,WistarKey words
somatostatin/diabetic retinopathy/electroretinogram/rats,Wistar分类
医药卫生引用本文复制引用
孙亚东,马彦,姜艳静,赵巧丹,关红,韩艳..生长抑素对糖尿病大鼠早期视网膜电图的影响[J].吉林大学学报（医学版）,2014,(6):1192-1196,5.基金项目
吉林省科技厅自然科学基金资助课题 （）
