吉林大学学报（医学版）Issue(6)：1256-1260,5.DOI:10.13481/j.1671-587x.20140627
Ck2α、β-catenin和survivin在卵巢癌组织中表达的检测及其临床应用价值
Detection of expressions of Ck2α,β-catenin and survivin in ovarian cancer tissue and its clinical application value
摘要
Abstract
Objective To study the expressions of casein kinase 2α(Ck2α),β-catenin, survivin in ovarian cancer tissue and analyze the relationships between them, and to explore the clinical application value. Methods Immunohistochemistry staining was used to detect the expressions of Ck2α,β-catenin and survivin in 8 cases of simple ovarian cysts tissue,8 cases of ovarian benign tumor tissue and 29 cases of ovarian cancer tissue;the correlations of the expressions of Ck2α,β-catenin,survivin in ovarian cancer tissue and their associations with the clinicopathologic characteristics were analyzed.Results The expression levels of Ck2α,β-catenin and survivin in ovarian cancer tissue were significantly higher than those in simple ovarian cysts tissue and ovarian benign tumor tissue(P<0.05);the Ck2αexpression level in ovarian cancer tissue was positively corelated with the expression levels ofβ-catenin and survivin(r=0.438,r=0.479,P<0.05);the expression levels of Ck2α,β-catenin and survivin in low-medium differentiation group were significantly higher than those in high differentiation group (P<0.05);the expression levels of Ck2α,β-catenin and survivin in stagesⅡandⅢ group were significantly higher than those in stage Ⅰ group(P<0.05).Conclusion The protein expression levels of Ck2α,β-catenin and survivin are increased in ovarian cancer tissue, and three are positive corelations between them;Ck2α,β-catenin and survivin may play an important role in the occurrence and development of ovarian cancer;the combined detection of them has important clinical value.关键词
酪蛋白激酶2α/β-catenin/survivin/卵巢肿瘤Key words
casein kinase 2α/β-catenin/survivin/ovarian neoplasms分类
医药卫生引用本文复制引用
吴爽,刘乙蒙,刘超,郭琳,肖建英..Ck2α、β-catenin和survivin在卵巢癌组织中表达的检测及其临床应用价值[J].吉林大学学报（医学版）,2014,(6):1256-1260,5.基金项目
辽宁省科技厅自然科学基金资助课题 （）
