滨州医学院学报Issue(3)：161-163,3.
IL-12和IL-12受体在刚地弓形虫感染致不良妊娠结局中的作用机制研究磁
IL-12 and IL-12R were related with adverse pregnancy outcomes induced by Toxoplasma gondii
摘要
Abstract
Objective To investigate whether IL-12 and IL-12 receptor (IL-12R) are related with adverse pregnancy outcomes induced by Toxoplasma gondii .Methods Twenty-four pregnant C57BL/6 mice were randomly divided into infection group (n=12) and control group (n=12) .Infection group mice were inoculated intraperitoneally with 400 tachyzoites on GD 8 and con-trol group mice were inoculated with same dose sterile PBS at the same time .All mice were euthanized on GD 14 ,placentas and fetuses were observed .IL-12 receptor levels expressed on mouse uterine natural killer cells (uNK) were detected using flow cy-tometry ,and IL-12 levels secreted in placentas were measured by ELISA .Results On GD 14 ,we found that the placentas from infected mice were hemorrhagic when compared to those of uninfected control mice ,which had a better blood supply .The still-birth rate of infected mice was significantly increased compared with that of control mice (P<0.01) .The levels of IL-12R ex-pressed on infected uterine NK cells were significantly increased relative to uninfected controls (P<0.05) ,and the levels of IL-12 were higher in samples from the infected group than from controls (P<0.05) .Conclusion The elevated expression levels of IL-12 and IL-12 receptor play an important role in adverse pregnancy outcomes caused by Toxoplasma gondii .关键词
IL-12/IL-12受体/刚地弓形虫/不良妊娠结局Key words
IL-12/IL-12 receptor/Toxoplasma gondii/Adverse pregnancy outcome分类
医药卫生引用本文复制引用
陈翠玲,刘志强,刘现兵,韩美玉,张玲,徐晓艳,胡雪梅..IL-12和IL-12受体在刚地弓形虫感染致不良妊娠结局中的作用机制研究磁[J].滨州医学院学报,2014,(3):161-163,3.基金项目
国家自然科学基金（81171591）及山东省自然科学基金 （）
