滨州医学院学报Issue(3)：182-184,222,4.
希罗达联合吉西他滨或长春瑞滨治疗晚期三阴性乳腺癌的临床观察
Clinical efficacy of capecitabine combined with gemcitabine or vinorelbine in the treatment of metastatic triple negative breast cancer
菅金波 1张鲁燕 2宁方玲 1李绵利 1王峰 1郝延璋 1陈绍水1
作者信息
- 1. 滨州医学院附属医院肿瘤科滨州 256603
- 2. 滨州市人民医院肿瘤科
- 折叠
摘要
Abstract
Objective To evaluate the clinical efficacy and tolerability of capecitabine-based combination chemotherapy in the treatment of the anthracycline and taxane-resistant metastatic TNBC .Methods All 38 patients with metastatic breast cancer were recruited to receive either GX regimen ( capecitabine 2.0 g/m2 ,bid ,d1-14 ,gemcitabine 1000mg/m2 ,d1 ,8 iv ) or NX regi-men (capecitabine 2.0 g/m2 ,bid ,d1-14 ,vinorelbine 25 mg/m2 ,d1 ,8 iv ) .There were twenty-one days in a cycle .Results All 38 patients completed 133 chemotherapy cycles with a four-cycle median per patients .The overall response rate (CR+ PR) was 18.4% and clinical benefit rate was (CR+ PR+SD) 44.7% .The median time of progression(PFS) was 7.6 months ,OS was 12.5 months .The efficacy between of different chemotherapy regimens wans not significantly different .No patient died due to chemotherapy .The main toxicity was myelosuppression and hand -foot syndrome .Conclusion The efficacy of capecitabine con-tained GX or NX regimen was relatively poor in mTNBC patients ,suggesting capecitabine -based combination chemotherapy may be considered to be acceptable ,but if it could be a preferred ,we need large sample and multi-center study .关键词
乳腺癌/三阴性/耐药/卡培他滨/疗效/不良反应Key words
Breast neoplasms/T riple-negative/Resistance/Capecitabine/Effect toxicity分类
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菅金波,张鲁燕,宁方玲,李绵利,王峰,郝延璋,陈绍水..希罗达联合吉西他滨或长春瑞滨治疗晚期三阴性乳腺癌的临床观察[J].滨州医学院学报,2014,(3):182-184,222,4.
