摘要
Abstract
Objective To analyze the risk factors of mild cognitive impairment (MCI) in elderly type 2 diabetic patients . Methods Montreal cognitive assessment scale (MoCA) and clinical dementia rating scale (CDR) were used as cognition assess‐ment tool .200 elderly type 2 diabetic patients with MCI (MCI group) and 60 elderly type 2 diabetic patients with normal cogni‐tive function (control group) were enrolled as subjects .Information of disease history ,blood pressure ,BMI ,FBG ,HbA1c , blood lipid ,serum creatinine ,plasma homocysteine (HCY) ,folic acid and vitamin B12 of all subjects were collected .Results There were statistically significant differences in the age ,level of education ,course of diabetes ,HbA1c ,history of hypertension , course of hypertension ,systolic blood pressure ,level of HCY ,folic acid and vitamin B12 between the MCI group and control group .No statistically significant differences were found in the gender composition ,BMI ,diastolic blood pressure ,fasting blood glucose ,blood lipid levels ,serum creatinine levels between the MCI group and control group .MoCA scores were positively cor‐related with level of education and folic acid ,and were negatively correlated with the age ,HbA1c ,history of hypertension , course of hypertension ,systolic blood pressure ,level of HCY .Multiple regression analysis showed that age ,HbA1c ,the history of hypertension and the level of HCY were independent risk factors for the MoCA scores .Conclusions Older age ,poor blood glucose control ,hypertension ,hyperhomocysteinemia might be risk factors for MCI in elderly type 2 diabetic patients .关键词
糖尿病 ,2型/轻度认知功能障碍/危险因素/蒙特利尔认知评估量表Key words
diabetes mellitus/type 2/mild cognitive impairment/risk factors/montreal cognitive assessment分类
医药卫生
