川北医学院学报Issue(4)：466-469,473,5.DOI:10.3969/j.issn.1005-3697.2015.04.11
多发性硬化和视神经脊髓炎患者血清尿酸和同型半胱氨酸水平分析
Analysis of serum uric acid and homocysteine levels in pateints with multi-ple sclerosis and neuromyelitis optica
摘要
Abstract
Objective:To investigate the serum uric acid( SUA) and homocysteine( HCY) levels in pateints with multiple sclero-sis,neuromyelitis optica and healthy people,and their relations among three groups. Methods:SUA and HCY levels were determined in 68 patients with MS,96 patients with NMO,as well as 100 healthy controls. UA and HCY levels were compared among groups according to the clinical characteristics such as age,sex,type and handicapped degree. Results:The SUA levels in patients with MS and NMO were significantly lower than those in the healthy control group. The HCY levels in patients with MS were significantly higher than those in the NMO group and healthy control group. In the MS group,the HCY levels in patients with EDSS score above 3. 5 were significantly higher than those in patients with EDSS score below 3. 5. Conclusion:Low SUA level and hyperhomocysteinemia may contribute to pathological mechanism of MS. The level of HCY may be associated with the severity of MS. Low SUA level may be correlated with the pathological mechanism of NMO.关键词
多发性硬化/视神经脊髓炎/同型半胱氨酸/尿酸Key words
Multiple sclerosis/Neuromyelitisoptica/Homocysteine/Uric acid分类
医药卫生引用本文复制引用
罗家明,陈蓉,王莉,柯莎,蒋国会,余巨明,秦新月..多发性硬化和视神经脊髓炎患者血清尿酸和同型半胱氨酸水平分析[J].川北医学院学报,2015,(4):466-469,473,5.基金项目
四川省卫生厅资助项目(110305) （110305）
