磁共振成像Issue(5)：321-327,7.DOI:10.3969/j.issn.1674-8034.2014.05.001
帕金森病静息态脑功能MRI研究
A resting-state functional MRI study in Parkinson's disease
摘要
Abstract
Objectives:Blood-oxygen-level dependent functional magnetic resonance imaging (BOLD-fMRI) was used to investigate the resting-state brain functional abnormalities in patients with Parkinson's disease (PD). Materials and Methods:Totally 68 clinically diagnosed PD patients with at least 12 hours withdrawal time and age-and gender-matched 36 normal controls (NC) were included to take clinical scale evaluation and resting-state BOLD-fMRI examination. All subjects were scanned with Philips 3.0 Tesla MRI system. The fMRI data were processed and analysed by DPARSF V2.0 soft and REST V1.8 soft. Two-sample t-test was used to examine the mALFF differences between PD group and NC group. Results: Compared to NC group, PD group had significantly decreased mALFF values in extensive brain regions including bilateral SMA, middle and posterior cingulate cortex, precuneus, hippocampus, parahippocampal gyrus, lateral globus pallidus, dorsal thalamus, anterior lobe of cerebellum, and right local primary motor cortex, insular cortex, caudate nucleus, putamen, posterior lobe of cerebellum as well as increased mALFF values in several brain regions including extensive cortex of bilateral anterior frontal, parietal and temporal lobe, and left occipital primary visual cortex (P<0.05, AlphaSim corrected). Conclusions:Resting-state brain functional abnormalities of PD patients are extensive. The neuronal activity decreases mainly in several areas including motor regulation related brain regions, default mode network and limbic system, and increases mainly in extensive cortex of anterior frontal, parietal, temporal lobe and primary visual cortex.关键词
帕金森病/磁共振成像/静息态Key words
Parkinson disease/Magnetic resonance imaging/Resting-state分类
医药卫生引用本文复制引用
彭帅,陈敏,李春媚,马欣昕,娄宝辉,罗晓捷,王蕊,苏闻..帕金森病静息态脑功能MRI研究[J].磁共振成像,2014,(5):321-327,7.基金项目
“十二五”国家科技支撑计划项目(编号2012BAI10B04) （编号2012BAI10B04）
