磁共振成像Issue(6)：408-415,8.DOI:10.3969/j.issn.1674-8034.2014.06.002
贝尔麻痹影响大脑默认模式网络的功能连接
Facial Bell’s palsy affects default mode network connectivity
摘要
Abstract
Objective:Bell’s palsy (BP) is common peripheral idiopathic disease affecting the facial nerve (CN VII) causing loss of control facial muscles on the affected side. We investigated BP’s effects on the resting state default mode network (DMN) connectivity due to neuroplasticity in brain.Materials and Methods:1.5 T- MRI scanner was used to aquire fMRI data over 35 healthy volunteers and 52 BP patients (Some of patients participated more than once) at different pathological stages (based on disease duration and House-Brackmann Score) in resting state. Dual regression independent component analysis (ICA) approach was used for functional connectivity analysis.Results: DMN connectivity had varied changes for different stages of BP. In early group, DMN connectivity was increased with right (r.) SI, r. MI, and r. DLPFC; while for late group it was increased with bilateral MCC, r. VMPFC, r. PCC, bilateral precuneus. For recovered group, DMN connectivity was increased with left (l.) lingual gyrus and l. cerebellum.Conclusions: BP induced different DMN brain connectivity changes with different brain regions such as sensorimotor, motor mapping, emotional regions and cognitive regions and this connectivity changes are varied between different pathological stages.关键词
功能磁共振成像/贝尔麻痹/功能连接/默认模式网络Key words
Functional magnetic resonance imaging/Bell’s palsy/Functional connectivity/Default mode network分类
医药卫生引用本文复制引用
Abdalla Z Mohamed,Chuanfu Li,Jeungchan Lee,Seulgi Eun,Yifang Zhu,Yuanyuan Wu,Jun Yang,Kyungmo Park..贝尔麻痹影响大脑默认模式网络的功能连接[J].磁共振成像,2014,(6):408-415,8.基金项目
国家重点基础研究发展计划项目(973)(编号2010cb530500)；国家自然科学基金(编号81202768，31171083，31230032)，安徽省自然科学基金(编号1208085mh147)；安徽省教育委员会重大科研项目(编号kj2011zd05) （973）
