磁共振成像Issue(6)：416-422,7.DOI:10.3969/j.issn.1674-8034.2014.06.003
经皮电针刺激正常人耳甲迷走神经的功能MRI脑效应研究
Brain response to transcutaneous electronical stimulation on auricular concha of the healthy subjects using fMRI
摘要
Abstract
Objectives: To investigate the BOLD fMRI response to transcutaneous vagus nerve electronical stimulation (tVNS) at auricular concha region (ACR) on the healthy. It is hypothesized that tVNS modulates the network of nucleus of tract solitary-limbic system. Materials and Methods: Sixteen healthy subjects (18-27 y) were enrolled in the fMRI study. The fMRI was conducted during tVNS on ACR controlled with sham-tVNS on the superior scapha respectively. Subjects’ sensations were recorded after every fMRI scan. Each functional scan lasted 6 minutes. SPM8 was employed for the fMRI data processing.Results: The current, and the sensations’ frequency and strength of electronical stimulation were similar between two groups. The tVNS induced the predominant deactivation in the left nucleus of tract solitary and brain regions involving in limbic function, and the activation was limited in left SII, left anterior insula, etc. However, the sham tVNS showed the deactivation in the areas of right nucleus of trigeminal nerve, the obvious activation in the somato-sensory areas. Conclusions: tVNS modulated the network of nucleus of tract solitary-limbic system. It would provide the basis of therapeutic mechanism of tVNS treating Depression.关键词
电针/耳甲部/经皮迷走神经刺激/功能磁共振成像/脑激活/脑负激活Key words
Electronical acupuncture/Auricular concha region/Transcutaneous vagus nerve electronical stimulation/Functional magnetic resonance imaging/Brain activation/Negative brain deactivation分类
医药卫生引用本文复制引用
方继良,刘志顺,朱兵,孔健,荣培晶,洪洋,范洋洋,刘军,马云遥,徐春华,王鸿红,马迎歌,王小玲..经皮电针刺激正常人耳甲迷走神经的功能MRI脑效应研究[J].磁共振成像,2014,(6):416-422,7.基金项目
北京市自然基金重点课题(编号71110070)；国家自然科学基金(编号30870668，81273674，81303056)；国家科技部科研条件领域科技计划项目(编号2012BAF14B10) （编号71110070）
