磁共振成像Issue(6)：423-429,7.DOI:10.3969/j.issn.1674-8034.2014.06.004
基于格兰杰因果分析的针刺不同效应阶段中枢神经传导通路研究
Heterogeneous neural pathways underlying acupuncture revealed by multivariate granger causality analyses
摘要
Abstract
Objectives: Although accumulating evidence has demonstrated a wide range of cortico-subcortical networks underlying acute effects of acupuncture, less is understood regarding how and by what neural pathways these brain areas interact. We have recently proposed that acupuncture is a slow-acting agent and can induce speciifc patterns of dynamic CNS activities. Implicit in this evidence was the prediction that the reconifguration of brain networks underlying both acute and sustained effects of acupuncture may elucidate its overall functional speciifcity.Materials and Methods:We address the idea directly by adopting a non-repeated event-related design paradigm and multivariate Granger causality analysis (mGCA).Results:We found that brain areas were only sparsely causal connected at early acupuncture needling stage, mainly including ascending path from the thalamus as well as top-down control signals from frontal cortices to nociceptive information processing areas. As time prolonged (sustained effect), more extensive regions integrated into a dense, causally interconnected network only following acupuncture at ST36 but not nonacupoint. Additionally, this reorganization of wide brain networks seemed to be evolved from the resting state.Conclusions:These findings highlighted that the specific effect of acupuncture may involve the integration of recurrent information lfow among multi-levels of brain networks.关键词
针刺/时间动态响应/特异性中枢神经传导通路/磁共振成像Key words
Acupuncture/Time-dependent activities/Heterogeneous neural pathways/Magnetic resonance imaging分类
医药卫生引用本文复制引用
孙传铸,白丽君,牛璇,陈红艳,陈鹏,张明,劳力行..基于格兰杰因果分析的针刺不同效应阶段中枢神经传导通路研究[J].磁共振成像,2014,(6):423-429,7.基金项目
国家自然科学基金项目(编号81371630)；陕西省科技新星项目(编号2014KJXX-34)；北京市科技新星计划(编号Z111101054511116)；北京市自然科学基金面上项目(编号4122082) （编号81371630）
