磁共振成像Issue(1)：27-32,6.DOI:10.3969/j.issn.1674-8034.2015.01.006
7.0TMRI对离体乳腺癌组织浸润范围判定的病理对照研究
The evaluation of the inifltration range of breast cancer tissue in vitro using 7.0 T MRI:a comparative study between MRI and histological examination
摘要
Abstract
Objectives:To evaluate the accuracy of inifltration range of breast cancer tissue in vitro using 7.0 T magnetic resonance imaging(MRI), and to verify the possible value of determining the breast tumor margin before surgery by MRI. Materials and Methods:Fresh breast cancer tissue in vitro (n=17) were underwent 7.0 T MRI and histological examination. After acquisition of diffusion weighted imaging (DWI)、apparent diffusion coefficient (ADC) and fractional anisotropy (FA) imaging on the 7.0 T MRI machines, the edge of lesion was drawn out manually and the area of tumor was calculated by VnmrJ 4.0. The HE dyeing slice of pathology was observed under a microscope. The edge of lesion was drawn out manually and the area was calculated by Photoshop software. The correlation between the area of tumor from MRI and the histological slice was analyzed using Pearson correlation test of SPSS version 19.0. Results:In all specimens, there were 14 cases of breast inifltrative ductal carcinoma, 2 cases breast papillary carcinoma and 1 case of mucinous breast carcinoma conifrmed pathologically. Signiifcant correlation was found between the area of breast tumor on DWI, ADC, FA mapping and histological result (4.32±1.28) cm2 in DWI vs. (3.81±1.12)cm2 in histological slice, Pearson correlation coefifcient r=0.966, P=0.00, (4.68±1.43) cm2 in ADC vs. (3.81± histological slice, Pearson correlation coefifcient r=0.976, P=0.00, (4.74±1.53) cm2 in FA vs. (3.81±1.12) cm2 in histological slice, Pearson correlation coefifcient r=0.964, P=0.00). Conclusions:Although all of the areas acquired by MRI were larger than those by histological results, there was signiifcant correlation between them. Thus, useful information for evaluating the inifltration range of breast tumor may be provided by MRI. 1.12) cm2 in histological slice, Pearson correlation coefficient r=0.976, P=0.00, (4.74±1.53) cm2 in FA vs. (3.81±1.12) cm2 in histological slice, Pearson correlation coefficient r=0.964, P=0.00). Conclusions: Although all of the areas acquired by MRI were larger than those by histological results, there was significant correlation between them. Thus, useful information for evaluating the infiltration range of breast tumor may be provided by MRI.关键词
乳腺肿瘤/磁共振成像/病变范围/病理学Key words
Breast neoplasms/Magnetic resonance imaging/Inifltration range/Pthology分类
医药卫生引用本文复制引用
陈业晞,钟晓平,李志扬,蔡道全,吴仁华,沈智威..7.0TMRI对离体乳腺癌组织浸润范围判定的病理对照研究[J].磁共振成像,2015,(1):27-32,6.基金项目
广东省科技计划项目基金项目(编号2012B031800425) （编号2012B031800425）
