磁共振成像Issue(5)：364-369,6.DOI:10.3969/j.issn.1674-8034.2015.05.009
1H MRS对初诊2型糖尿病患者胰腺脂肪沉积的量化及与胰岛β细胞功能的关系研究
1H MRS quantiifcation of ectopic fat accumulation in pancreas and its relationship with islet beta-cell function in patients with newly diagnosed type 2 diabetes mellitus
摘要
Abstract
Objective: To in vivo quantify the pancreatic fat content in newly diagnosed type 2 diabetes mellitus (T2DM) by applying1H MRS, and investigate its relationships with liver fat content, serum triglyceride (TG) and islet beta-cell function. Materials and Methods: Fifty-eight T2DM subjects and thirty-two volunteers without T2DM were included in this study. All T2DM subjects were newly diagnosed according to the clinical criteria without any therapy. The pancreatic spectroscopy of at least one location (head, body, and tail) and liver spectroscopy at right lobe were acquired by single-voxel PRESS sequence on 3.0 T MR scanner. The pancreas fat content (PFC) and liver fat content (LFC) were calculated in each case.Spearman correlations between PFC and LFC, TG, the body mass index (BMI), the fasting blood-glucose (FBG), the fasting serum insulin (FINS), the homeostasis model assessment of insulin resistance (HOMA-IR), the homeostasis model assessment-β (HOMA-β)and the Lee-Bennett islet beta cell function index (MBCI) were performed in order to visualize their relationships.Results:The mean values of PFC in 58 T2DM subjects and 32 volunteers without T2DM were (16.09±6.27)% and (14.56±7.97)%, respectively, there is no statistically difference (P>0.05). The LFC in 32 T2DM subjects and all volunteers without T2DM was successfully measured, the mean values were (21.13±14.44)% and (12.43±12.19)%, respectively, there was statistically signiifcant differences (P=0.006). Moderate to low correlations were found between PFC and LFC (r=0.502,P=0.003), TG (r=0.467,P=0.007), and BMI (r=0.362,P=0.042) in volunteers without T2DM, but no statistical correlation was found between PFC and LFC, TG, BMI, FBG, FINS, HOMA-IR, HOMA-β, and MBCI (r<0.15,P>0.05) in T2DM subjects.Conclusions:No correlation was found between PFC and LPF, TG, and islet beta-cell function in patients with newly diagnosed T2DM.关键词
脂肪过多/糖尿病, 2型/磁共振波谱学/胰腺疾病/脂肪肝Key words
Adiposity/Diabetes mellitus, Type 2/Magnetic resonance spectroscopy/Pancreatic diseases/Fatty liver分类
医药卫生引用本文复制引用
刘朋,柴军,洪旭,尹洁,于恒池,苏天昊,张洁,史凯宁,靳二虎..1H MRS对初诊2型糖尿病患者胰腺脂肪沉积的量化及与胰岛β细胞功能的关系研究[J].磁共振成像,2015,(5):364-369,6.基金项目
北京市自然科学基金(编号7122048) （编号7122048）
