磁共振成像Issue(6)：455-461,7.DOI:10.3969/j.issn.1674-8034.2015.06.012
动态增强MRI定量评价类风湿性关节炎腕关节炎症活动度的价值
The value of quantitative evaluation of inlfammatory activity by using wrist dynamic contrast-enhanced MRI in rheumatoid arthritis
摘要
Abstract
Objective: To investigate the value of quantitative evaluation of inflammatory activity by using wrist dynamic contrast-enhanced MRI (DCE-MRI) in rheumatoid arthritis (RA) patients.Materials and Methods: Twenty patients with clinically and pathologically proved RA underwent wrist DCE-MRI examination, Krenn scoring of synovial inflammatory, clinical scoring of DAS28 and serological examination. Quantitative parameters including the volume transfer constant (Ktrans), rate constant (Kep), extravascular extracellular volume fraction (Ve), plasma volume (Vp) and semi-quantitative parameters including the time to peak (TTP), maximum concentration(Cmax), the area under concentration-time curve (AUC), maximum slope (Slopemax) of wrist synovial lesions were derived from DCE-MRI data. Relationship between quantitative and semi-quantitative parameters and Krenn scores of synovial inlfammatory, clinical score of DAS28 and serological results were analyzed by using correlation analysis. Ktrans values between different grades of synovitis were analyzed by using Studentt test.Results:The average Ktrans value of 20 patients was (1.27 ± 0.59) ml/min, the average Krenn score was 3.38 ± 1.53, and the average DAS28 score was 4.80 ± 0.94. Pathologically, six patients had high-grade synovitis and eleven patients had low-grade synovitis. Positive correlation was found between Ktrans and Krenn scores,as well as between Ktrans and DAS28 scores (r=0.698,P<0.01;r=0.510,P<0.05 respectively). However, no correlation was found between Kep, Ve, Vp, TTP, Cmax, AUC, Slopemax and Krenn scores, DAS28 scores, serological results (P>0.05). Ktrans values in high-grade synovitis group were higher than these in low-grade synovitis group (t=4.05,P<0.01).Conclusion:Ktrans values derived from DCE-MRI can be used to relfect the clinical and pathological inlfammatory activity of RA.关键词
磁共振成像/动态增强/关节炎,类风湿/腕关节Key words
Magnetic resonance imaging/Dynamic contrast-enhancement/Arthritis, Rheumatoid/Wrist Joint分类
医药卫生引用本文复制引用
曾伟科,莫颖倩,张翔,段小慧,陈乐锋,马剑达,戴冽,沈君..动态增强MRI定量评价类风湿性关节炎腕关节炎症活动度的价值[J].磁共振成像,2015,(6):455-461,7.基金项目
教育部新世纪优秀人才支持计划资助(编号NCET-11-0538)；广东省科技计划项目(编号2013B021800222) （编号NCET-11-0538）
