磁共振成像Issue(6)：467-470,4.DOI:10.3969/j.issn.1674-8034.2015.06.014
磁共振扩散加权成像在家兔肝纤维化分期的诊断价值
Aassessment of diffusion-weighted imaging in staging liver ifbrosis in rabbits
摘要
Abstract
Objective: To evaluate the accuracy of apparent diffusion coefifcient(ADC) correlates on staging liver ifbrosis.Materials and Methods:The study consisted of three groups: HF group (n=32), control group (n=15) and supplemental group (n=12). Rabbits from control and HF group underwent conventional MRI and DWI scan and the liver ADC values were measured. In HF group, eight rabbits randomly underwent MRI examinations at 4, 5, 6, 10 weeks after CCl4 administration. The correlation between ADC values and HF stages was assessed. The diagnostic performance of DWI for staging HF was compared using the receiver operating characteristic curve analysis on the basis of the histopathologic analysis of HF.Results:Signiifcant differences of ADC values were present among HF stages (F=5.344,P<0.005). The ADC values were correlated with the HF stages (r=-0.630,P<0.001). Sensitivity, specificity, positive (PPV) and negative predictive values (NPV) were for≥S1: 75.00%, 55.56%, 85.70%, 38.50%, respectively; for≥S2: 79.2%, 58.8%, 73.1%, 66.7%; for≥S3: 87.5%, 80.0%, 73.70%, 90.9%; for S4: 87.50%, 66.67%, 38.90%, 95.7%.Conclusion:DWI can offer important assistance in staging HF as a non-invasive technique.关键词
肝纤维化/肝硬化/磁共振扩散加权成像/兔Key words
Liver fibrosis/Liver cirrhosis/Magnetic resonance imaging, diffusion weighted/Rabbits分类
医药卫生引用本文复制引用
邓乾华,阮继银,江锦赵,冯飞,谢家钧,邹立秋..磁共振扩散加权成像在家兔肝纤维化分期的诊断价值[J].磁共振成像,2015,(6):467-470,4.基金项目
广东省科技计划项目(编号2011B031800385) （编号2011B031800385）
