摘要
Abstract
Objective: To investigate the diagnostic value of parameters derived from diffusion-weighted imaging intravoxel incoherent motion (IVIM) model for benign and malignant breast lesions, and compare these parameters with that of monoexponential model and dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI). Materials and Methods: Seventy cases (23 cases of benign lesions in total 24, 47 cases of malignant lesions in total 48) of breast disease with breast MRI examination in our hospital were collected. All of them were examined with multiple-b-value diffusion-weighted imaging (DWI) and DCE-MRI scans. GE AW4.4 workstation was used to calculate the value of ADC, ADCstandard, D, D*, f, and to generate time-signal intensity curve (TIC). All parameters between benign and malignant breast lesions were compared byMann-Whitney U test. The diagnostic performance of different parameters was evaluated by receiver operating characteristic curve (ROC curve) analysis.Results:The ADC, ADCstandard, D, f value of malignant lesions were (1.01±0.18)×10-3 mm2/s, (1.10±0.18)×10-3 mm2/s, (0.86±0.16)×10-3 mm2/s, (25.50±9.23) % respectively, benignlesions were (1.42±0.29)×10-3 mm2/s, (1.53±0.27)×10-3 mm2/s, (1.28±0.26)×10-3 mm2/s, (15.98±3.68) %. There were statistically signiifcant differences between these parameters (P<0.001). With ROC curve analysis for each parameter value, the area under the curve (AUC) of D value was 0.932 which was the highest one, and corresponding diagnostic sensitivity and speciifcity were 89.6%and 91.7% while taking the optimal threshold of 1.03×10-3 mm2/s. AUC value can be increased to 0.974 by combining D with f value, and the corresponding diagnostic sensitivity and speciifcity were 85.4% and 100% respectively.Conclusions:The ADCstandard, D and f value from the IVIM model can be used to distinguish benign from malignant breast lesions. Associated with D and f value can obtain better diagnostic performance than the ADC value and the TIC.关键词
弥散磁共振成像/乳腺肿瘤/体素内不相干运动Key words
Diffusion magnetic resonance imaging/Breast neoplasms/Intravoxel incoherent motion分类
医药卫生
