重庆医学Issue(10)：1208-1210,3.DOI:10.3969/j.issn.1671-8348.2014.10.020
肝母细胞瘤中的干细胞表面标记物的初步识别
Preliminary recognition of stem cells surface markers in hepatoblastoma
摘要
Abstract
Objective To preliminarily screen the neoplastic stem cell (NSC) related surface markers combination and to under-stand the NSC distribution in hepatoblastoma(HB) .Methods The children cases of HB undergone the surgical therapy in the Jian-gxi Provincial Children′s Hospital were selected .The immunohistochemical method was adopted for observing the expression and distribution of NSC-related markers CD34 ,Thy-1 ,c-kit ,CD56 and stem cell factor(SCF) in the HB tissue and the normal hepatic tissue away from the edge of tumor tissue 3cm outside .Results Thy-1 and c-kit were sporadically distributed in the HB tissue and mainly focued on the portal area ,but did not exressed in the normal liver tissue ;the expression of CD34 and SCF in HB was signifi-cantly higher than that in the normal liver tissue(P<0 .05) ,in which CD34 was mainly distributed in the endothelial system and SCF was mainly expressed in the portal area ;CD56 was expressed in the tissue of the clustered nerve fibers ,the expression differ-ence between them had no statistical significance (P>0 .05) .Conclusion The different NSC related surface markers are distributed in the HB tissue and focus on the specific areas .The positive cells of Thy-1/c-kit expression may play a role in the HB occurrence .关键词
肿瘤干细胞/肝母细胞瘤/抗原,CD34/抗原,Thy-1/原癌基因蛋白质c-kitKey words
neoplastic stem cells/hepatoblastoma/antigens ,CD34/antigens ,Thy-1/proto-oncogene proteins c-kit引用本文复制引用
张守华,肖菊花,邓庆强,徐红艳,罗鸣,谌卫龙,雷俊,陶强..肝母细胞瘤中的干细胞表面标记物的初步识别[J].重庆医学,2014,(10):1208-1210,3.基金项目
江西省卫生厅课题资助项目（20131137）。 （）
