摘要
Abstract
Objective To investigate the expression of AuroraA,CyclinD1,CyclinB1 and Bcl-2 in BTCC with regard to the clini-cal significance.Methods Expressions of AuroraA,CyclinD1 ,CyclinB1 and Bcl-2 were detected by immmunohistochemical staining in 5 6 cases of BTCC and 1 5 cases of normal bladder tissues as controls.The relevance between the expressions of AuroraA,Cy-clinD1 ,CyclinB1 and Bcl-2 and the clinical pathology of the patients of BTCC were studied.Results Immmunohistochemical stai-ning demonstrated that the positive rate of AuroraA,CyclinD1,CyclinB1 and Bcl-2 respectively was 51.8%(29/56),46.4%(26/56),75.0%(42/56)and 62.5%(35/56)in BTCC,which is significantly higher than normal bladder tissues as 13.3%(2/15),6.7%(1/15),33.3%(5/15)and 6.7%(1/15)(P<0.01)respectively.The positive rate of AuroraA,CyclinB1 and Bcl-2 were significant-ly positive correlated with the grade of the tumor(P<0.05),but CyclinD1 with negative correlation.And no correlation was found between The positive rate of CyclinB1、Bcl-2 and clinical staging,but AuroraA with positive correlation and Bcl-2 with negative one. There was a significantly verse relationship between the positive rate of AuroraA and CyclinD1(r=0.508,P<0.01),but a positive correlation between AuroraA and CyclinB1(r=0.594,P<0.01)、Bcl-2(r=0.535,P<0.01).Conclusion AuroraA could exert in-fluence on the expression of CyclinD1、CyclinB1 and Bcl-2.关键词
癌,移行细胞/膀胱肿瘤/AuroraA/细胞周期蛋白D1/细胞周期蛋白B1/Bcl-2Key words
carcinoma,transitional cell/urinary bladder neoplasms/AuroraA/cyclinD1/cyclinB1/Bcl-2
