重庆医学Issue(16)：2026-2027,2031,3.DOI:10.3969/j.issn.1671-8348.2014.16.019
感染性脑损伤中橙皮苷对小鼠自主活动的影响
Effect of hesperidin on locomotor activity of mice with infective brain injury induced by LPS
摘要
Abstract
Objective To study the effect of hesperidin on the locomotor activity of mice with infective brain injury induced by li-popolysaccharide (LPS)in the dark field environment.Methods 45 ICR mice were randomly divided into 3 groups:Saline group, LPS group and LPS+Hesperidin group,15 mice in each group.The moving distance and the number of crossing line in the dark field were recorded using the ZH-ZFT locomotor activity video analysis system.ResultsThe LPS group had significantly shorter moving distance as well as lower frequency of the number of crossing line than those of the Saline group(P<0.05);compared with the LPS group,the Hesp group moved longer and crossed line more frequently,the differences between the two groups had statisti-cal significance (P<0.05).Conclusion Hesperidin could significantly improve the capacity for action in the dark field of mice with infective brain inj ury induced by LPS.关键词
脑损伤/橙皮苷/自主活动Key words
brain-inj-uries/hesperidin/locomotor-activity引用本文复制引用
吴健,刘永海,宋远见,刘红芝,温相如,付燕燕,张磊,孙颖,张芳,刘永民,董红燕..感染性脑损伤中橙皮苷对小鼠自主活动的影响[J].重庆医学,2014,(16):2026-2027,2031,3.基金项目
国家自然科学基金资助项目（31100762，81371300）；江苏省高校自然科学研究项目（11KJB310013，13KJB310021）；徐州医学院院长基金资助项目（2012KJZ06）。 （）
