重庆医学Issue(17)：2134-2136,3.DOI:10.3969/j.issn.1671-8348.2014.17.009
血清细胞因子水平与结直肠癌患者发生抑郁的关系研究
Relationship between serum cytokines and depression in patients with colorectal cancer
吴天山 1郭永健 2董笑言 3关丽4
作者信息
- 1. 新疆医科大学第一附属医院急救中心外科，乌鲁木齐 830054
- 2. 新疆医科大学第一附属医院泌尿外科，乌鲁木齐，830054
- 3. 新疆维吾尔自治区巴楚县人民医院普外科 843800
- 4. 新疆医科大学第一附属医院消化内科，乌鲁木齐 830054
- 折叠
摘要
Abstract
Objective To explore the correlation between serum cytokines and the depression degree in the patients with colorec-tal cancer.Methods 9 6 cases of colorectal cancer were selected and divided into 2 groups according to the patients health question-naire(PHQ-9):the depression group (52 cases)and the non-depression group (44 cases),and 40 healthy cases were recruited as the control.Serum interleukin-2 (IL-2),soluble interleukin-2 receptor (SIL-2R)and tumor necrosis factor-α(TNF-α)were detected by enzyme-linked immunosorbent assay(ELSIA).The detection results were compared among various groups.And the correlation be-tween the expression of various cytokines and the depression degree was analyzed by the Pearson′s correlation coefficient.Results The levels of IL-2,SIL-2R and TNF-αhad statistical differences among 3 groups (P<0.05);no statistical difference in the TNF-αexpression was noted between the depression and the non-depression groups (P>0.05),but which in these two groups was higher than that in healthy group (P<0.05);the IL-2 level in the depression group was significantly lower than that in the non-depression group(P<0.05);the SIL-2 R level in the depression group was obviously higher than that in the non-depression group (P<0.05), moreover,which in these two groups was higher than that in the healthy group (P<0.05).By correlation analysis,the depression degree in the patients with colorectal cancer was negatively correlated with the IL-2 level (r=-0.259,P<0.05)and positively correlated with the SIL-2R level(r=0.412,P<0.05).Conclusion The levels of IL-2 and SIL-2R have certain correlation with the depression degree in the patients with colorectal cancer,it is speculated that the above cytokines may play a mediating role in the pathogenesis process of depression in the colorectal cancer patients.关键词
抑郁/结直肠肿瘤/细胞因子Key words
depression/colorectal-neoplasms/cytokines引用本文复制引用
吴天山,郭永健,董笑言,关丽..血清细胞因子水平与结直肠癌患者发生抑郁的关系研究[J].重庆医学,2014,(17):2134-2136,3.
