重庆医学Issue(17)：2164-2166,2169,4.DOI:10.3969/j.issn.1671-8348.2014.17.019
电针对非酒精性脂肪肝大鼠肝细胞角蛋白18表达的影响
Influence of Electroacupuncture intervention on liver CK1 8 expression in nonalcoholic fatty liver rats
摘要
Abstract
Objective To investigate the influence of electroacupuncture(EA)intervention on liver CK18 expression in nonalco-holic fatty liver (NAFL)rats.Methods Wistar rats were randomly divided into the normal group and the model group.After suc-cessfully establishing the rat model,the model group was redivided into the NAFLD group,drug group and EA group.The drug group was fed with Dongbao Gantai by gavage and the EA group was performed the EA acupuncture at the specific points of unilat-eralPishu,Fenglong,YanglingquanandSanyinj iao.After 4-week treatment,all animals were killed and the live histopatho-logical changes were observed.The contents of liver malondialdehyde (MDA)and superoxide dismutase (SOD)were detected by the colorimetric method.The liver CK18 expression was detected by the mmunohistochemical method.Results Compared with the model group,the steatosis of the liver tissue in the EA group and the drug group were alleviated to different extents;expression of hepatic CK18 was suppressed;liver MDA was decreased with various degrees (P<0.01;P<0.05)and the SOD activity was in-creased (P<0.01;P<0.05).Conclusion Electroacupuncture may reduce lipid peroxidation by inhibiting the up-regulation of he-patic CK18 expression.关键词
电针/脂肪肝/细胞角蛋白18Key words
electroacupuncture/fatty-liver/cytokeratin-1-8引用本文复制引用
曾志华,曾明慧,黄学宽,周萍,陈康..电针对非酒精性脂肪肝大鼠肝细胞角蛋白18表达的影响[J].重庆医学,2014,(17):2164-2166,2169,4.基金项目
重庆市卫生局中医药科技计划项目（2011-2-146）。 （）
