重庆医学Issue(18)：2303-2304,2311,3.DOI:10.3969/j.issn.1671-8348.2014.18.015
比较小檗碱对 HEPG2蛋白质组的抗肿瘤作用
Comparative proteomic study on antitumor effect of berberine on human hepatocellular carcinoma cell line HEPG2
摘要
Abstract
Objective To research the effects of berberine on the protein expression of human hepatocellular carcinoma cell line HEPG2 for elucidating its antitumor mechanism.Methods The change of protein expression of human hepatocellular carcinoma cell line HEPG2 induced by berberine were analyzed by using comparative proteomics.Results A total of 38 differentially expressed protein spots were detected.16 protein spots were up-regulated and 22 protein spots were down-regulated.10 protein spots were successfully identified by the mass spectrum.Conclusion The berberine antitumor effect may be related with PPARγsignal trans-duction pathway,PPARγmay be the target of berberine.关键词
小檗碱/蛋白质组学/抗肿瘤Key words
berberine/proteomics/antitumor引用本文复制引用
陈华,谷容,赵晓东,刘雯,袁拥华..比较小檗碱对 HEPG2蛋白质组的抗肿瘤作用[J].重庆医学,2014,(18):2303-2304,2311,3.基金项目
重庆市卫生局中医处课题（2009-2-47）。 （）
