重庆医学Issue(20)：2545-2547,3.DOI:10.3969/j.issn.1671-8348.2014.20.001
冠心病介入术患者血管内皮依赖性舒张功能与血小板L-精氨酸／一氧化氮通路的关系
The relation between endothelium-dependent vasodilator function and platelet L-arginine/nitric oxide pathway in patients with percutaneous coronary intervention
摘要
Abstract
Objective To investigate alteration and cross link of the vascular endothelium dependent diastolic function (FMD) and platelet endogenous L-arginine/NOS/NO pathway before and after percutaneous coronary intervention (PCI) .Methods The study included two groups :normal control group(17 cases) and PCI group(20 cases) .FMD of brachial artery and NO production , NOS activity ,L-arginine transport in platelets were examined respectively before ,immediately ,24 h and 72 h after PCI and the rela-tionships between them would subsequently be analysed .Results The preoperative FMD ,content of NO2 - ,NOS activity and L-ar-ginine of PCI group significantly decreased than the normal control group (P<0 .01) ,and further decreased in the immediate post-operative(P<0 .01) .Gradually recovered 24 h after surgery ,72 h after surgery ,the FMD ,NO2 - ,L-arginine transport ,NOS activity restored to the preoperative level (P>0 .05) .The analysis showed the obvious positive correlation between FMD and content of NO2 - or NOS activity ,or L-arginine transport of platelet ,respectively(P<0 .01) .Conclusion The pathway of platelet L-arginine/NOS/NO was significantly positively correlated with FMD and the detection of platelet L-arginine/NOS/NO can reflect the changes of vascular endothelial function with PCI .关键词
一氧化氮/经皮冠状动脉介入术/内皮依赖性舒血管功能/一氧化氮合酶/L-精氨酸转运Key words
nitric oxide/percutaneous coronary intervention/vascular endothelium dependent diastolic function/nitric oxide syn-thase/L-arginine transport分类
医药卫生引用本文复制引用
问慧娟,李亚芹,崔玉英,李玉巧..冠心病介入术患者血管内皮依赖性舒张功能与血小板L-精氨酸／一氧化氮通路的关系[J].重庆医学,2014,(20):2545-2547,3.基金项目
河北省科学技术研究与发展计划项目（11276103D-7）；河北省卫生厅重点科技研究计划项目（20100141 ）；河北大学医学学科专项资金建设项目（2013A2001）。 （）
