重庆医学Issue(20)：2548-2550,3.DOI:10.3969/j.issn.1671-8348.2014.20.002
血必净注射液对慢性阻塞性肺疾病急性加重期患者免疫功能的影响
The effects of Xuebijing injection on immune function of patients with acute exacerbation of chronic obstructive pulmonary disease
摘要
Abstract
Objective To investigate the clinical effects of Xuebijing injection on immune function of patients with acute exacer-bation of chronic obstructive pulmonary disease(AECOPD) .Methods 103 patients with AECOPD were divided into 3 groups ,in-cluding control group(33 cases) ,the treatment group 1(36 cases) and treatment group 2(34 cases) .The conventional treatments of COPD including anti-infection ,relieving cough ,expectorant ,antispasmodic ,anti-asthmatic and aerosol therapy were adopted in all patients ,based on the similar conventional therapy in the control group ,50 mL Xuebijing injection with NS 250 mL(1/d ,course of 7 d) were added in the treatment group 1 ,and 100 mL Xuebijing injection with NS 250 mL (1/d ,course of 7 d)were added in the treatment group 2 .Serum CD3 ,CD4 ,CD8 ,CD4/CD8 and IgA ,IgG ,IgM were tested before treatment as well as 4 days and 8 days after treatment .The condition changes in all patients were evaluated .Results After 8 days of treatment ,the total treatment effi-ciency and serum CD3 ,CD4 ,CD4/CD8 ,IgA were significantly changed in the two treatment groups compared with the control group(P<0 .05) ,but serum CD8 ,IgG ,IgM showed no significant difference(P>0 .05);After 4 days of treatment ,the total efficien-cy and serum CD4 ,CD4/CD8 were significantly changed in the treatment group 2 which injection dose was increased compared with the control group(P<0 .05) .The total treatment efficiency and immune function showed no significant difference between the two treatment groups(P>0 .05) .Conclusion Xuebijing injection can improve the immune function and treatment efficiency of AECO-PD patients .Appropriately increase the dose can achieve better clinical results in a short period .In conclusion ,Xuebijing injection is a feasible and effective method for the clinical treatment of AECOPD .关键词
肺疾病 ,慢性阻塞性/血必净注射液/免疫功能Key words
pulmonary disease ,chronic obstructive/Xuebijing injection/immunologic function分类
医药卫生引用本文复制引用
潘玲,毛德强..血必净注射液对慢性阻塞性肺疾病急性加重期患者免疫功能的影响[J].重庆医学,2014,(20):2548-2550,3.基金项目
重庆卫生局科研课题面上项目 （）
