重庆医学Issue(21)：2689-2690,2694,3.DOI:10.3969/j.issn.1671-8348.2014.21.001
系统性红斑狼疮患儿外周血滤泡辅助性T细胞相关细胞因子及受体表达水平研究
Study of follicular helper T lymphocytes related cytokines and receptors in children with systemic lupus erythematosus
摘要
Abstract
Objective To study the change of the plasma concentrations of follicular helper T lymphocytes (TFH cells) related cytokines and receptors in children with systemic lupus erythematosus (SLE) .Methods The plasma concentrations of TFH-cells-related cytokine IL-21 and CXCL13 ,and cell surface expression of TFH-related receptor CXCR5 and IL-21R on CD19+B cells in 22 SLE children and 20 sex-and age matched control subjects were measured by enzyme-linked immunosorbent assay and flow cytome-try ,respectively .Results Plasma CXCL13 and IL-21 concentrations were significantly higher in SLE children than controls (all P<0 .01) .Cell surface expression of CXCR5 on B cells was significantly lower in SLE children than controls (P<0 .05) .However ,the cell surface expression of IL-21R had no significant changes between SLE children and controls(P>0 .05) .Conclusion The elevat-ed production of CXCL13 and IL-21 may be associated with the function of TFH for the immunopathogenesis in SLE children .关键词
红斑狼疮 ,系统性/儿童/白细胞介素21/趋化因子CXCL13/滤泡辅助性T细胞Key words
lupus erythematosus ,systemic/child/interleukin-21/chemohine CCL13/follicular helper T lymphocytes分类
医药卫生引用本文复制引用
赵洁,曾莉,陈元,刘来成,陈大鹏..系统性红斑狼疮患儿外周血滤泡辅助性T细胞相关细胞因子及受体表达水平研究[J].重庆医学,2014,(21):2689-2690,2694,3.基金项目
国家自然科学基金青年基金项目（81300006）；重庆市科委资助项目（cstc2013jcyjA1027）。 （）
