重庆医学Issue(22)：2881-2883,3.DOI:10.3969/j.issn.1671-8348.2014.22.018
文拉法辛对卒中后抑郁患者认知功能改善的影响
Influence of Venlafaxine improving cognitive function in patients with post stroke depression
范建江 1张晓曼 1郭耀强1
作者信息
- 1. 河南省郑州市第一人民医院神经内科 450004
- 折叠
摘要
Abstract
Objective To observe the efficacy and safety of venlafaxine on cognitive function in patients with post stroke depres-sion(PSD) .Methods 72 patients of cognitive dysfunction with PSD were selected and randomly divided into observation group and control group with 36 cases in each .The control group was treated with therapy for acute stroke .The observation group was treated with venlafaxine based on the treatment of control group .After 12 weeks of treatment ,the mini mental state examination(MMSE) , the Montreal cognitive assessment scale(MoCA) and activities of daily living scale(ADL) were used to evaluated the efficacy of the two groups before ,fourth weeks after and twelfth weeks after the treatment .The scores of the two groups were compared .The oc-currence of adverse reaction of the observation group was recorded .Results After 4 weeks treatment of the observation group ,the MoCA was (18 .52 ± 4 .37) .MMSE score was (20 .61 ± 4 .85) ,which were significantly higher than before treatment .And the ADL score was (35 .27 ± 4 .75) ,significantly lower than before treatment(all P<0 .05) .After 12 weeks of treatment ,the MoCA score of observation group was (20 .14 ± 5 .26) .MMSE score was (22 .46 ± 4 .59) .Which were all significantly higher than those of control group .While the ADL score was (29 .85 ± 5 .07) ,significantly lower than the control group(all P<0 .05) .The observation group with 2 cases had mild gastrointestinal discomfort ,2 cases with dizziness .Conclusion Venlafaxine can improve cognitive function in patients with post stroke depression .It can significantly improve patients′self-care ability and is safe .It can be further applied in the clinic .关键词
文拉法辛/卒中/抑郁/认知功能Key words
venlafaxine/stroke/depression/cognitive function分类
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范建江,张晓曼,郭耀强..文拉法辛对卒中后抑郁患者认知功能改善的影响[J].重庆医学,2014,(22):2881-2883,3.
