重庆医学Issue(23)：3005-3007,3010,4.DOI:10.3969/j.issn.1671-8348.2014.23.011
BM PRⅠa在人脑胶质瘤中的表达
Expression and significance of BMPR Ⅰa in human glioma
摘要
Abstract
Objective To detect the expressions of BMPR Ⅰa of BMPs/BMPR/Smads signaling transduction pathway in human brain glioma ,to research the role of its in tumorigenesis and progression of brain glioma and its correlation to clinical pathology . Methods The mRNA and protein expressions of BMPR Ⅰa was detected in 20 normal brain tissues and 40 samples with human glioma by RT-PCR and SABC immunohistochemical methods ,repectively ,and analyzed the correlation with the patient′s age ,gender and pathological grade .Results Compared with normal brain tissues ,BMPR Ⅰa mRNA and protein expressions in human glioma were reduced significantly ,especially in Ⅲ and Ⅳ stage tumor tissues .The difference was not related with the patient′s age and gender .Conclusion In progression of glioma ,BMPR Ⅰa may play a role in restraining ,and has nothing to do with age and sex .关键词
脑胶质瘤/BM PRs/逆转录-聚合酶链式反应/免疫组织化学Key words
glioma/BMPRs/signal transduction pathways/RT-PRCR/immunohistochemistry分类
医药卫生引用本文复制引用
陈彩霞,邹杰,李素珍,鲍玉洲,步星耀..BM PRⅠa在人脑胶质瘤中的表达[J].重庆医学,2014,(23):3005-3007,3010,4.基金项目
河南省科技创新杰出人才计划项目资助（084200410011）。 （）
