重庆医学Issue(24)：3124-3126,3.DOI:10.3969/j.issn.1671-8348.2014.24.002
不同孕期妇女尿液甲状腺功能相关激素含量变化
Content change of urinary thyroid hormone parameters during pregnancy
摘要
Abstract
Objective To further research the urinary monitoring of the maternal thyroid functional status ,the levels of urine thyroid hormones were analyzed during pregnancy .Methods This study recruited 30 cases of healthy pregnant women at 9-12 ges-tational weeks .Their random urine specimens were collected every four weeks until delivery .The concentrations of urine thyrotro-pin(uTSH) ,urine free triiodothyronine(uFT3) and urine free tetraiodothyronine(uFT4) were detected by electrochemical lumines-cence immunoassay(ECLIA) .The urine retinol binding protein(uRBP) was detected by enzyme immunoassay (EIA) .After correc-ted by uRBP ,the statistical analysis was done to analyze the variation of the ratio of uTSH and uRBP (uTSH/uRBP) ,the ratio of uFT3 and uRBP(uFT3/uRBP)and the ratio of uFT4 and uRBP(uFT4/uRBP)during pregnancy .Results The median levels of u-rine thyroid hormone parameters were obtained from the healthy pregnant women every four weeks and were compared among dif-ferent stages .The difference of uFT3/uRBP and uFT4/uRBP was statistically significant (F= 6 .222 ,P< 0 .05 ;F= 5 .078 ,P<0 .05) ,and the levels of them varied linearity during pregnancy (F=27 .480 ,P<0 .05 ;F=23 .959 ,P<0 .05) .The difference of uT-SH/uRBP had no statistical significance(F=2 .731 ,P=0 .054) .Conclusion After corrected by uRBP ,the levels of uFT3 and uFT4 of healthy pregnant women decreased linearity among different gestational stages ,and the levels of uTSH had no noticeable change .关键词
妊娠/尿液分析/促甲状腺激素/游离三碘甲状腺原氨酸/游离甲状腺素Key words
pregnancy/urinalysis/thyrotropin/free triiodothyronine/free tetraiodothyronine分类
医药卫生引用本文复制引用
蔡佳,张曼,赵旭宏,雷婷,孟倩,周慧..不同孕期妇女尿液甲状腺功能相关激素含量变化[J].重庆医学,2014,(24):3124-3126,3.基金项目
国家科技支撑计划项目（2013BAI12B01-4）。 （）
