重庆医学Issue(24)：3130-3132,3.DOI:10.3969/j.issn.1671-8348.2014.24.004
首发儿童青少年精神分裂症脑磁共振弥散张量成像研究
A diffusion tensor imaging study of white matter in first episode neuroleptic-naïve early-onset schizophrenia
摘要
Abstract
Objective To investigated cerebral structural connectivity and its relationship to neuroleptic-naïve individuals with first episode early-onset schizophrenia using diffusion tensor imaging (DTI) which could demonstrate the white matter integrity . Methods We recruited subjects with first episode DSM-Ⅳearly-onset schizophrenia who had never been exposed to antipsychotic medication(n=19) and sex ,age-matched healthy volunteers (n= 19) .All subjects received DTI and structural magnetic resonance imaging scans .Voxel-based analysis was performed to investigate brain regions fractional anisotropy (FA) values .Results Statistics revealed that schizophrenia patients showed significant FA reduction in left inferior frontal gyrus ,left temporal gyrus ,left occipital lobe and right middle temporal gyrus as compared to healthy subjects .Conclusion Deficits of white matter integrity in widespread brain regions of the first episode neuroleptic-naïve early-onset schizophrenia patients .The presence of white matter abnormalities in the early-onset patients is suggestive of being related to the etilology of schizophrenia .关键词
早发精神分裂症/磁共振/弥散张量成像/白质纤维/各向异性Key words
early-onset schizophrenia/magnetic resonance imaging/diffusion tensor imaging/white matter/fractional anisotropy分类
医药卫生引用本文复制引用
姜红燕,李宗芳,杨涛,许秀峰,程宇琪,边海月,钱晶晶,田伟..首发儿童青少年精神分裂症脑磁共振弥散张量成像研究[J].重庆医学,2014,(24):3130-3132,3.基金项目
云南省教育厅科学研究基金资助项目（08Y0242）。 （）
