重庆医学Issue(24)：3146-3148,3.DOI:10.3969/j.issn.1671-8348.2014.24.009
干预血尿酸水平对老年高血压合并糖尿病患者一级终点事件的研究
Research on the effects in primary end point events of uric acid intervention to old age hypertension patients with diabetes mellitus
摘要
Abstract
Objective In order to discuss the contribution and significance of lowering increased serum uric acid levels in cardio-vascular disease prevention and control .Methods All 100 hyperuricemia in senile patients with hypertension and diabetes mellitus were received the standard drug treatments for bloodpressure ,blood sugar management .According to the patients′will divided them into uric acid intervention group(study group) and control group .The study group were given low purine diet and benzbromarone tablet (50 mg/day ,course of 1 year) ,then compare the changes between the 2 group and within each group after 3months ,6months and 1 years in the metabolism indexes before and after intervention (serum uric acid ,glycosylated hemoglobin ,fasting blood glu-cose ,2-hours postprandial glucose ,and the changes of dynamic blood pressure ) ,and follow-up the occurrence of cases in primary end point events (all-cause death ,total cardiovascular death) .Results (1)In study group ,3months ,6months and 1 years after in-tervention ,the serum uric acid lever was significantly lower than that before intervention and the control group ,P<0 .01 .(2)The study group patients′dynamic blood pressure was significantly lower than that before intervention and the control group after 6 ,12 months ,meanwhile the study group patients′success rate of dynamic blood pressure level is higher than themselves before the in-tervention after 6 ,12 months ,P<0 .05 .(3)The 2 groups of patients′glycosylated hemoglobin ,fasting plasma glucose ,2-hours post-prandial glucose ,control rate of blood glucose at each testing point before and after the intervention had no difference .(4)The oc-currence of cases between the 2 groups for all-cause death and total cardiovascular death had no difference .Conclusion (1)Reduc-ing the mortality and disability rate of hyperuricemia in elderly patients with hypertension and diabetes mellitus ,the most critical measures is still a reasonable standard blood pressure and blood sugar management .Based on this therapy ,effectively reducing the increased serum level of uric acid can improve the control rate of blood pressure .关键词
高尿酸血症/高血压/糖尿病Key words
hyperuricemia/hypertension/diabetic mellitus分类
医药卫生引用本文复制引用
常颂桔,杨波,王洪雄,姜桂花,罗永丽,黄伟..干预血尿酸水平对老年高血压合并糖尿病患者一级终点事件的研究[J].重庆医学,2014,(24):3146-3148,3.基金项目
云南省科技厅云南省应用基础研究面上项目（2010CD123）。 （）
