重庆医学Issue(26)：3409-3411,3415,4.DOI:10.3969/j.issn.1671-8348.2014.26.001
银杏黄酮对非酒精性脂肪肝病小鼠肝脏NF-κBp65和TNF-α的影响
Effects of gingko flavonoid on expression of NF-κBp65 and TNF-αin mice with non-alcoholic fatty liver disease
摘要
Abstract
Objective To investigate the effects of different doses of gingko flavonoid on the expression of nuclear factor-κBp65 (NF-κBp65) and tumor necrosis factor-α(TNF-α) in mice with non-alcoholic fatty liver disease(NAFLD) .Methods The mice mod-el of NAFLD was constructed by the high fat diet for 4 weeks .The mice were randomly divided into the control group ,high fat model group ,high ,middle and low doses of gingko flavonoid groups .High ,middle and low doses of gingko flavonoid groups were respectively gavaged with the different doses of gingko flavonoid .The normal control group and the high fat model group were ga-vaged with normal saline .After 12 weeks ,the mice were killed for taking liver tissue and detecting NF-κBp65 expressions ,and ser-um TNF-αand triacylglycerol(TG) levels were detected .Results Compared with the normal control group ,the levels of NF-κBp65 ,TNF-αand TG in the high fat model group were increased(P<0 .05) .Compared with the high fat model group ,the levels of NF-κBp65 ,TNF-αand TG in the high ,middle and low doses of gingko flavonoid groups were decreased (P<0 .05) ,moreover the higher the dose ,the more obvious the decrease .Conclusion Gingko flavonoid may play certain role in the treatment of NAFLD by reducing the generation of NF-κBp65 ,TNF-αand TG .关键词
黄酮类/银杏/植物提取物/脂肪肝/肿瘤坏死因子α/核因子-κBp65Key words
flavonoid/gingko biloba/plant extracts/fatty liver/tumor necrosis factor-alpha/nuclear factor-κBp65分类
医药卫生引用本文复制引用
林秋香,周冬生,白纪红,梁志清,赵雪,王雪雯..银杏黄酮对非酒精性脂肪肝病小鼠肝脏NF-κBp65和TNF-α的影响[J].重庆医学,2014,(26):3409-3411,3415,4.基金项目
国家自然科学基金资助项目（81260078）；广西自然科学基金资助项目（2012GXNSFAA276038）；广西壮族自治区卫生厅计划课题资助项目（Z2012421）。 （）
