重庆医学Issue(26)：3436-3438,3.DOI:10.3969/j.issn.1671-8348.2014.26.010
尿毒清联合 ARB／ACEI治疗糖尿病肾病大量蛋白尿的疗效观察
Efficacy observation on Uremic Clearance Granule combined with ARB or ACEI for treating massive proteinuria in patients with diabetic nephropathy
胡勤锦 1闫振成2
作者信息
- 1. 重庆市第七人民医院内分泌肾病科 400054
- 2. 第三军医大学大坪医院/野战外科研究所高血压内分泌科，重庆400042
- 折叠
摘要
Abstract
Objective To observe the effects of Uremic Clearance Granule combined with angiotensin receptor blockers (ARB) or angiotensin converting enzyme inhibitors (ACEI) in treating different period of diabetic nephropathy (DN ) .Methods 46 patients with DN were divided into the control group and the treatment group ,23 cases in each group .The two groups were given the rou-tine hypoglycemic therapy .The control group was treated with ACEI or ARB ,while the treatment group was given Uremic Clear-ance Granule 5 g each time ,four times daily for successive 4 weeks .Then the indexes of serum creatinine ,blood urea nitrogen ,cysta-tin-C ,microalbumin and 24 h urine total protein at 24 h before and after treatment were observed .Results The microalbumin and 24 h urine total protein after treatment in the two groups were reduced compared with before treatment (P<0 .01) .In the patients with the stage Ⅲ of DN ,the urine protein decrease after treatment had no statistical difference between the two groups (P>0 .05) . In the patients with the stage Ⅳ of DN ,on the basis of ACEI or ARB adding Uremic Clearance Granule could significantly decrease the urine protein(P<0 .05) .Conclusion ACEI or ARB combined with Uremic Clearance Granule has definite effect for treating massive proteinuria of DN .关键词
尿毒清颗粒/糖尿病肾病/血管紧张素转换酶抑制药/血管紧张素受体拮抗剂Key words
Uremic Clearance Granule/diabetic nephropathies/angiotensin-converting enzyme inhibitors/angiotensin receptor blockers分类
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胡勤锦,闫振成..尿毒清联合 ARB／ACEI治疗糖尿病肾病大量蛋白尿的疗效观察[J].重庆医学,2014,(26):3436-3438,3.
