重庆医学Issue(28)：3722-3723,2.DOI:10.3969/j.issn.1671-8348.2014.28.008
CA125和 HE4蛋白在卵巢癌组织及血清中的表达及其临床意义探讨
Expression of CA1 2 5 and HE4 protein in ovarian cancer tissue and serum and discussion of its clinical significance
刘连红 1罗建祥 1徐月君 1马艳华1
作者信息
- 1. 武警广东省总队医院检验科，广州 510507
- 折叠
摘要
Abstract
Objective To investigate the carbohydrate antigen 125(CA125)and human epididymis protein 4(HE4)in ovarian cancer tissue and serum expression and its clinical diagnosis value.Methods 48 cases of benign ovarian lesions in our hospital from January 2011 to July 2012 were collected as group A,45 cases of ovarian cancer patients were collected as group B,and the other 50 cases over the same period were selected as the healthy control group(group C),the elbow vein blood on the empty stomach were taken,and detected by electrochemical luminescence for serum CA125 level,and the serum HE4 were analyzed by ELISA method. The CA125 and HE4 in three groups were compared by statistical methods.Results The CA125 and HE4 in group B were signifi-cantly higher than that of the group A and group C(P<0.05);A group of CA125 and HE4 levels were higher than group C,and the difference has no statistically significant(P>0.05);sensitivity and specificity of CA125 and HE4 diagnostic were 95.56% and 97.78%,which were significantly higher than that of CA125 and HE4 alone diagnostics(P<0.05).Conclusion CA125 and HE4 in diagnosis of ovarian cancer can significantly improve the sensitivity and specificity of diagnostic and help the early diagnosis of ovar-ian cancer and disease surveillance,which has good clinical value.关键词
抗原,肿瘤相关,碳水化合物/人附睾蛋白4/卵巢肿瘤Key words
antigen,tumor-associated,carbohydrate/human epididymis protein 4/ovarian naoplasms分类
医药卫生引用本文复制引用
刘连红,罗建祥,徐月君,马艳华..CA125和 HE4蛋白在卵巢癌组织及血清中的表达及其临床意义探讨[J].重庆医学,2014,(28):3722-3723,2.
