重庆医学Issue(28)：3763-3765,3768,4.DOI:10.3969/j.issn.1671-8348.2014.28.022
氯沙坦短期用药对高血压前期大鼠血压和心肌的后效应
The after-effect of short-term use of losartan on blood pressure and myocardium in prehypertension rats
朱岫芳 1石根勇 2王静 1周少林 1杨友田1
作者信息
- 1. 盐城卫生职业技术学院药学院 江苏盐城 224001
- 2. 江苏省疾病预防控制中心毒理室 江苏南京 210000
- 折叠
摘要
Abstract
Objective To observe the influence of losartan on rats′blood pressure and myocardium.Methods To randomly divide 24 4-year-old spontaneously hypertensive male rats into 3 groups.Group A is given normal saline(NS);group B is given losartan 20 mg/kg in 4-week-old;group C is given the same dose in 1 2-week-old;To take another 4-week-old male wistar rats to form group D,feed NS served as normal comparison.Each group was given NS or losartan one time each day through intragastric administration for 4 weeks.Follow up 24 weeks after stopping the medicine.Rats’SBP were measured through tail cuff method respectively when at 4,8,12,16,20 and 24 weeks’ time.After 24 weeks,cut off the head to take the sample,the RVW/BW,HW/BW,LVW/BW were measured through weighing method.To observe the morphologic change of the cardiac muscles and measure the area of myocardium cell cross section through HE stain method.Ra-dioimmunoassay was used to measure the AngⅡand Aldo level of the blood plasma and myocardium.Results At the age of eight-week,the SBP of group A and C are higher than those of group D(P<0.05),group B significantly lower than group A.After stopping the medicine, SBP of group B is slowly increasing and still lower than group A(P<0.05)as well as group C (P<0.05)until the 24th week.At the 16th week,SBP of group C is significantly lower than that of group A(P<0.05)but higher than group D,but quickly increases after stopping the medicine till the 24th week and there is no significant difference between group A and C(P>0.05).About LVW/BW,HW/BW and the ar-ea of myocardium cell cross section,group A increased significantly in comparison with group D (P<0.05),group B and C decreased in comparison with group A(P<0.05),group B decreased significantly in comparison with group C(P<0.05).Through the observation of the area of myocardial cell cross section under the microscopy,group A increased significantly in comparison with group D about myocardial cell fattened and the gap between cells are widened,the fibers of mesenchyma proliferates.group B and D are similar,group C is between group B and A.The level of AngⅡand Aldo in plasma and myocardium of group A increased significantly in comparison with group D (P<0.05),group B decreased significantly in comparison with group A and C(P<0.05).Conclusion To use losartan for a short time in trea-ting rats with prehypertension can get the after-effect of reducing blood pressure and anti-ventricular-remodeling.关键词
氯沙坦/高血压/短期用药/后效应Key words
losartan/hypertension/short-term medication/after-effect分类
医药卫生引用本文复制引用
朱岫芳,石根勇,王静,周少林,杨友田..氯沙坦短期用药对高血压前期大鼠血压和心肌的后效应[J].重庆医学,2014,(28):3763-3765,3768,4.
