重庆医学Issue(29)：3866-3869,4.DOI:10.3969/j.issn.1671-8348.2014.29.007
大肠息肉癌变相关危险因素分析
A analysis of the risk factors of colorectal polyp malignant transformation
摘要
Abstract
Objective Colorectal polyp is a precancerous lesion of colorectal cancer .Aim of the study was to explore the risk fac-tors of colorectal polyp malignant transformation .Methods The related information of 75 084 colonoscopies performed from 2003 to 2012 in Southwest Hospital in Chongqing were collected and the relationship between polyp malignant transformation and the pa-tient age ,sex ,polyp location ,size or histological types was analyzed .Results From 2003 to 2012 ,polyps were diagnosed in 14 806 cases of the total 75 084 patients with a 19 .72% detection rate .There were significant difference of the left-side and right-side pol-yp detection rate in different age groups ,and the frequency of polyps distributed in the whole colorectum increased with the increase of age .The rates of epithelial neoplasia and malignant transformation increased with age .At the same time ,malignant transforma-tion rate was significant higher in polyps located in left-side than that in right-side (P<0 .0167) ,in adenoma than that in inflamma-tory hyperplastic polyp (P<0 .01) .The larger diameter and the more villus ,the higher rate of malignant transformation .Conclusion Patient age ,polyp size ,location and histological type could be considered as the significant predictors of colorectal polyp malignant transformation .It may be useful to treat the polyp with endoscopy in patient with age more than 45 and adenoma whose diameter was not less than 1 cm ,located in left-side for prevention of colorectal cancer .关键词
肠息肉/腺瘤/病理学/上皮内瘤变/癌变Key words
intestinal polyps/adenoma/pathology/epithelial neoplasia/malignant transformation分类
医药卫生引用本文复制引用
于晓娜,彭贵勇,房殿春,邵顺子,沈才飞,张昊翔,王璞,夏一菊,李靖文,张安然,徐胤..大肠息肉癌变相关危险因素分析[J].重庆医学,2014,(29):3866-3869,4.基金项目
国家自然科学基金项目资助（81071727）。 （）
