重庆医学Issue(29)：3904-3906,3.DOI:10.3969/j.issn.1671-8348.2014.29.019
食管癌根治手术围术期多模式镇痛的临床研究
Clinical research of peri-operative multimodality analgesia in open chest radical operation patients with esophageal carcinoma
摘要
Abstract
Objective To investigate the efficacy and safety of multimodal analgesia and patients controlled intravenous analgesia (PCIA) on peri-operative pain in open chest radical operation patients with esophageal carcinoma .Methods Eighty patients with e-sophageal carcinoma underwent open chest radical operation were randomly divided into 2 groups :multimodal analgesia group (group A ,n=40) and simple PCIA group(group B ,n=40) .Patients in group A were injected dexmedetomidine 1 μg/kg through vein by a micro-infusion pump within 10 min before incision ,and blocked the intercostal nerves at the cut and the chest tube places and the upper and lower intercostal nerves of the cut .Patients in group B were injected equal amount of saline as a control in the same way .Patients in both groups were undertaken sufentanil PCIA immediately at the end of the operation .Observation of the VAS score ,sedative and comfortable state ,patients controlled analygesia(PCA) pressing times ,using dosage and side effects of sufentanil on these patients at 2nd ,4th ,6th ,12th ,24th ,48th hour after operation were taked .Results Compared with group B , VAS score ,the dosage of sufentanil ,PCA pressing times ,nausea ,vomiting ,pruritus ,abdominal distension ,respiratory depression and side effects of sufentanil in group A significantly decreased ,and the comfortable score significantly increased .The differences have statistically significant(P<0 .05) .Sedation score between group A and group B has no significant difference(P>0 .05) .Con-clusion Compared with PCIA ,the multimodal analgesia is more effective ,and has less adverse reaction after open chest radical op-eration in patients with esophageal carcinoma .关键词
围术期/镇痛/食管肿瘤/临床研究Key words
peri-operation/analgesia/esophageal neoplasms/clinica study分类
医药卫生引用本文复制引用
冯慧,李清,罗向红,熊良志..食管癌根治手术围术期多模式镇痛的临床研究[J].重庆医学,2014,(29):3904-3906,3.基金项目
湖北省教育厅科研项目（B20102107）。 （）
