重庆医学Issue(31)：4169-4171,4174,4.DOI:10.3969/j.issn.1671-8348.2014.31.017
白藜芦醇对动脉粥样硬化兔血脂及血清中抗氧化酶水平的影响
Resveratrol regulates serum lipid and antioxidant enzymes level in an atherosclerotic rabbit model
摘要
Abstract
Objective This study was designed to investigate influence of resveratrol on serum lipid and antioxidant enzyme lev‐els in atherosclerotic rabbit model ,and to explore its influence on NF‐κB and MAPKs signal pathway .Methods Rabbits were as‐signed to five groups :control (group A) ,high fat diet group (group B) ,resveratrol group (group C ,D and E) .The contents of lip‐ids level (TC ,TG ,LDL‐C ,HDL‐C) and antioxidant enzyme (GSH ,GSH‐PX ,GST ,γ‐GCS ,CAT ,SOD ,MDA) levels in the serum were measured respectively and the difference was studied .Phosphorylation levels of MAPKs cascades ,NF‐κB were measured by Western blot .Results Compared with group A ,group B had elevated levels of blood lipids ,antioxidant enzymes were on the de‐cline ,the MDA content increased ,MAPKs and the NF‐κB protein phosphorylation enhanced .C ,D ,E group can reduce levels of blood lipids ,increases HDL‐C ,improve antioxidant enzyme activity and reduce MDA content ,inhibit MAPKs ,NF‐κB protein phos‐phorylation .Conclusion Resveratrol could reduce the atherosclerotic rabbit blood lipid levels ,increase antioxidant enzyme activity , reduce the MDA level and this effect is likely to inhibit NF‐κB and MAPKs signaling pathway activation .关键词
NF-κB/动脉粥样硬化/白藜芦醇/血脂/氧化应激/MAPKs 信号通路Key words
NF-kappa B/atherosclerosis/resveratrol/serum lipid/antioxidant effect/MAPKs signal path分类
医药卫生引用本文复制引用
宋蕊,陈艳宇,李婉秋,窦健霖,张戈,孙林..白藜芦醇对动脉粥样硬化兔血脂及血清中抗氧化酶水平的影响[J].重庆医学,2014,(31):4169-4171,4174,4.基金项目
教育部留学回国人员科研启动基金；云南省应用基础研究面上项目（2008CD122）；云南省教育厅重点项目（2010Z034）；云南省科技厅－昆明医科大学联合专项基金资助（2011FB193）。 （）
