重庆医学Issue(31)：4206-4209,4.DOI:10.3969/j.issn.1671-8348.2014.31.029
DNM T1、PDCD4在舌鳞状细胞癌中的表达及临床意义
Expression and clinical significance of DNMT1 and PDCD4 in tongue squamous cell carcinoma
王倩 1唐维平 1魏智艺 2金丹丹3
作者信息
- 1. 南昌大学第二附属医院口腔科，南昌 330006
- 2. 中国人民解放军第 180 医院烧伤整形科，福建泉州 362000
- 3. 广东医学院检验学院，广州 510000
- 折叠
摘要
Abstract
Objective To investigate the expression of DNM T1 and PDCD4 in Tongue Squamous cell carcinoma and their signif‐icance to Clinical .Methods The protein expression of DNM T1 and PDCD4 in 40 cases of TSCC tissues and The adjacent no tumor tissues were measured by Elivision Two Step immunohistochemical method(IHC) ,the relationship between DNM T1 ,PDCD4 and clinicopathological parameters were analyzed .Results There was positively over expression of DNM T1 while the expression of PD‐CD4 was at a low lever or lost in TSCC tissues ,the expression of two genes DNM T1 and PDCD4 in the adjacent no tumor tissues were in contrast ;there was a significant negative correlation between DNM T1 and PDCD4 expression in TSCC(r = - 0 .452 ,P<0 .05) .The expression of DNM T1 protein were associated with histopathological differentiation types ,regional lymph node metasta‐sis and TNM staging(P< 0 .05) ,it had nothing to do with age and gender ;the expression of PDCD4 protein were associated with regional lymph node metastasis and TNM staging(P< 0 .05) ,and it had nothing to do with age ,gender ,histopathological differenti‐ation types .Conclusion Implying the abnormal expression of DNM T1 and PDCD4 protein might be closely related to the develop‐ment and progression of TSCC .DNM T1 may be participates in the inactivation of PDCD4 expression ,and led to the development of the cancer at last .关键词
DNA 甲基转移酶 1/程序性细胞死亡因子 4/舌鳞状细胞癌/蛋白表达/临床病理特征Key words
DNA methyltransferase 1/programmed cell death 4/tongue squamous cell carcinoma/expression of proteins/clinico-pathological characteristics分类
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王倩,唐维平,魏智艺,金丹丹..DNM T1、PDCD4在舌鳞状细胞癌中的表达及临床意义[J].重庆医学,2014,(31):4206-4209,4.
