重庆医学Issue(32)：4311-4313,3.DOI:10.3969/j.issn.1671-8348.2014.32.012
白芍总苷辅助治疗SLE对患者外周血CD4＋CD25＋T细胞表达的影响
The effect of TGP assisted treatment of SLE on the expression of CD4+CD25+T in patient peripheral blood
摘要
Abstract
Objective to investigate the effect of TGP assisted treatment of SLE on the expression of CD4+CD25+ T in patient peripheral blood .Methods flow cytometry was used to detect the peripheral blood CD4+ CD25+ T cells in healthy group ,routine group and TGP group .Results The expression rate of CD4+CD25+ T cells in SLE patients was (6 .15 ± 1 .21)% ,and that of the healthy controls was (12 .30 ± 1 .78)% .The expression rate of CD4+CD25+ T cells in active SLE patients and healthy controls were significantly different (t=22 .03 ,P<0 .05) .In the routine group ,the expression rate of peripheral blood CD4+CD25+ T cells before and after treatment were significantly different (t= 12 .30 ,P<0 .05);in the TGP group ,the expression rate of peripheral blood CD4+ CD25+ T cells before and after treatment were significantly different ,too (t=16 .68 ,P<0 .05) .The expression rate of periph‐eral blood CD4+CD25+ T cells in routine group and TGP group were (9 .34 ± 1 .37)% and (11 .49 ± 1 .14)% respectively ,and the difference was statistically significant (t=6 .46 ,P<0 .05) .Conclusion The expression rate of CD4+ CD25+ T cells in active SLE patients was significantly lower than that of healthy controls ;the expression rate of CD4+CD25+ T cells in SLE patients increased significantly after treatment .The TGP treatment may work on CD4+CD25+ T cells .关键词
红斑狼疮,系统性/流式细胞术/CD4+CD25+T细胞/白芍总苷Key words
lupus erythematosus ,systemic/flow cytometry/CD4+CD25+ T cells/TGP分类
医药卫生引用本文复制引用
钟益萍,米向斌,张堂德,孙乐栋..白芍总苷辅助治疗SLE对患者外周血CD4＋CD25＋T细胞表达的影响[J].重庆医学,2014,(32):4311-4313,3.基金项目
国家自然科学基金青年资助项目（81201233）。 （）
