重庆医学Issue(33)：4440-4443,4446,5.DOI:10.3969/j.issn.1671-8348.2014.33.008
上皮间质转化标志物 Vimentin和 E-cadherin在颅咽管瘤中的表达及其临床意义
Expression and roles of the epithelial mesenchymal transition markers Vimentin and E-cadherin in craniopharyngioma
摘要
Abstract
Objective To assess the different protein expressions of epithelial mesenchymal transition (EM T ) markers Vimentin and E‐cadherin in craniopharyngioma ,especially at the tumour invasive front ,and correlate the findings with clinicopathological fea‐tures and patient outcomes .Methods Forty‐two craniopharyngiomas were subjected to the detection of Vimentin and E‐cadherin by immunohistochemistry and double immunofluorescence staining .The relationships between expression of these markers and various clinico pathological indicators and clinical outcomes of these tumors were analyzed .Results There was statistically significant difference in the expression of Vimentin and E‐cadherin between adamantinomatous and papillary variants in whole tumor and at the tumor invasive front .The expression of Vimentin and E‐cadherin in whole tumor sections were associated with tumor recurrence , postoperative weight and hypothalamic disturbances ,and the expression of vimentin and E‐cadherin at the tumor invasive front were colligated with tumor recurrence ,postoperative weight and hypothalamic disturbances .Conclusion Our study exemplifies the po‐tential prognostic implications of Vimentin and E‐cadherin expression in craniopharyngioma .EM T may represent a crucial mecha‐nism in the progression of adamantinomatous craniopharyngioma .关键词
颅咽管瘤/上皮间质转化/Vimentin/E-cadherinKey words
craniopharyngioma/epithelial mesenchymal transition/vimentin/E-cadherin分类
医药卫生引用本文复制引用
周杰,张超,潘军,陈礼刚,漆松涛..上皮间质转化标志物 Vimentin和 E-cadherin在颅咽管瘤中的表达及其临床意义[J].重庆医学,2014,(33):4440-4443,4446,5.基金项目
广东省自然科学基金重点项目（S2012020010939）；泸州市科技计划项目计划［2013-S-48（26／30）］；泸州医学院校级基金资助项目（2013ZRZD005）。 （）
