重庆医学Issue(35)：4719-4722,4.DOI:10.3969/j.issn.1671-8348.2014.35.005
透明质酸水凝胶修复大鼠软骨缺损的实验研究
Experiment study on the repairing effect of hyalurnic acid hydrogel on rat articular cattilage defects
赵峰 1何薇 2刘桂兰 3张国平 1王辉 1石硕 1刘少俊 1田德虎2
作者信息
- 1. 河北医科大学第一医院骨科，石家庄050031
- 2. 河北医科大学第三医院手外科，石家庄050051
- 3. 河北医科大学第一医院VIP病房，石家庄050031
- 折叠
摘要
Abstract
Objective To observe the repairing effect of hyaluronic acid hydrogel on rat articular cartilage defects .Methods One hundred and twenty SD rats were randomly divided into group A (natural repair group) ,group B (hyaluronic acid group) and group C (composite material group) ,36 rats was in each group and 12 rats were used to obtain cartilage cells .Full‐thickness articular os‐teochondral defects(2 .5 mm in diameter and 3 .0 mm in depth)were created mechanically in femoral trochlea of rats .Histological and biochemical method were used to evaluate the repairing effect of different material at different points(10 ,20 ,40 d) .Results Repairing effect of group C was best by histological and biochemical method at different points ,followed by group B ,and they were better than that of group A .Conclusion Hyaluronic acid hydrogel could provide cartilage cell proliferation for porous space truss structure ,and could carry cartilage cells at the same time .the cellular space truss structure have high surrounding tissue compatibil‐ity and biodegradation ,it is helpful for cartilage cell survival ,reproduction and division .关键词
透明质酸/生物相容性材料/关节软骨/修复外科手术Key words
hyaluronic acid/biocompatible materials/articular cartilage/reconstructive surgical procedures分类
医药卫生引用本文复制引用
赵峰,何薇,刘桂兰,张国平,王辉,石硕,刘少俊,田德虎..透明质酸水凝胶修复大鼠软骨缺损的实验研究[J].重庆医学,2014,(35):4719-4722,4.
