重庆医学Issue(36)：4854-4856,3.DOI:10.3969/j.issn.1671-8348.2014.36.003
先天性心脏病继发重度肺动脉高压患者的肺活检研究
Study on lung biopsy in patients with severe pulmonary hypertension secondary to congenital heart disease
摘要
Abstract
Objective To investigate the nature of the pulmonary arterioles in the patients with severe pulmonary hypertension secondary to congenital heart disease .Methods All patients with congenital heart disease and secondary severe pulmonary hyper‐tension(PH) were selected by using diagnostic‐treatment to undergo the radical repair(n= 49) .The lung biopsy specimens were ob‐tained during operation .The nature of pulmonary vascular disease (PVD) was determined by Heath‐Edwards classification system . All specimens were quantitatively analyzed by calculating the arteriole medial area percentage ,medial thickness percentage and arte‐riole density .Results The transcutaneous oxygen saturation in all selected patients was increased significantly after diagnostic‐treatment(P< 0 .01) .There was no case of operative death .The postoperative mean pulmonary artery pressure and pulmonary vas‐cular resistance were decreased significantly (P < 0 .01) .38 cases (77 .6% ) showed the H‐E grade Ⅰ change ,5 cases (10 .2% ) showed the H‐E grade Ⅱ change ,4 cases(8 .2% ) showed the H‐E grade Ⅲ chfange and only 2 cases (4% ) showed the H‐E gradeⅣ change with plexiform lesion .Conclusion The pulmonary vessels in the selected patients with severe PH secondary to congenital heart disease by using the diagnostic‐treatment are generally reversible and still feasible for performing the radical operation .关键词
肺动脉高压/先天性心脏病/肺血管病/可逆性/先进肺动脉高压治疗Key words
pulmonary hypertension/congenital heart disease/pulmonary vascular disease/reversible/advanced PH therapy分类
医药卫生引用本文复制引用
黄景彬,梁健,赵晓芳,杜茗,朱耀斌,刘迎龙..先天性心脏病继发重度肺动脉高压患者的肺活检研究[J].重庆医学,2014,(36):4854-4856,3.基金项目
国家自然基金资助项目（30972958）；国家自然基金资助项目（81360014）；广西科技关项目（2013B［26236］）；广西自然基金资助项目（2014GXNSFAA118234）；广西卫生厅项目（GZP13-27）。 （）
