摘要
Abstract
Objective To systematically evaluate the association between interleukin‐6 gene polymorphism and rheumatoid ar‐thritis(RA) susceptibility in countrymen .Methods Case‐control studies(CCS) on the association between interleukin‐6 gene poly‐morphism and rheumatoid arthritis susceptibility in countrymen were retrieved by computer from Pubmed ,Cochrane library ,Sci‐verse ,CNKI ,VIP ,CBM and Wanfang database from their establishment to Sep ,2013 .According to the inclusion and exclusion crite‐ria ,two reviewers independently screened the CCS .The meta analysis adopted the Revman 5 .0 software ,the publication bias was assessed by the Stata 11 .0 software .Results A total of three CCS were included .The meta analysis revealed that G allele and re‐cessive model(GG vs .GC + CC) of the IL‐6‐174 gene polymorphism had certain relation with RA susceptibility (P < 0 .01 ,P <0 .01) ,but the dominant models(GG + GC vs .CC) and homozygote type(GG vs .CC) did not show this relation(P = 0 .18 ,P =0 .13) .In the IL‐6‐572C/G polymorphism sites ,the homozygote type ,recessive models ,dominant models and alleles had no relation with the RA susceptibility(P = 0 .64 ,0 .92 ,0 .05 ,respectively ) .Conclusion The G allele and recessive models of IL‐6‐174 G /C gene polymorphism may be associated with the RA susceptibility in countrymen .关键词
白细胞介素-6/类风湿性关节炎/基因多态性/Meta 分析Key words
interleukin-6/rheumatoid arthritis/polymorphisms/Meta analysis分类
医药卫生
